Iron-deficiency anaemia, gastric hyperplasia, and elevated gastrin levels due to potassium channel dysfunction
Home of Kyle J. Norton for The Better of Living & Living Health Potassium makes up 1% of a person’s total body weight and is a very important mineral for the proper function of all cells, tissues, and organs in the human body found abundantly in Swiss Chard, Lima Beans, Potatoes, Yam, Soybeans and all meats and fish, etc.
Iron-deficiency anaemia, gastric hyperplasia, and elevated gastrin levels due to potassium channel dysfunction
A history of iron-deficiency anaemia in 12 of 14 patients and subjective gastrointestinal symptoms in 13 of 14 patients was revealed. Previous endoscopy in five cases had revealed no case of coeliac or inflammatory bowel disease but three cases of mucosal hyperplasia/dysplasia. Current signs of anaemia or iron substitution were present in 9 of 12 tested cases. Elevated levels of gastrin in seven of nine cases, pepsinogen in six of seven cases, and faecal calprotectin in nine of nine cases were present. A significant correlation between elevated gastrin levels and concurrent iron-deficiency and/or anaemia was revealed (p-value 0.039). A high frequency of extra-cardiac clinical symptoms and previous medical investigations was found. We propose that the Jervell and Lange-Nielsen Syndrome phenotypically includes gastrointestinal symptoms/signs and secondary iron-deficiency anaemia owing to hypochlorhydria on the basis of KCNQ1 mutations(18).
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Sources
(18) http://www.ncbi.nlm.nih.gov/pubmed/22805636
http://medicaladvisorjournals.blogspot.com
2012-11-30 19:40:18
Source: http://medicaladvisorjournals.blogspot.com/2012/11/iron-deficiency-anaemia-gastric.html
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