Potassium and Gastrointestinal (GI) functional and motility disorders
Home of Kyle J. Norton for The Better of Living & Living Health Potassium makes up 1% of a person’s total body weight and is a very important mineral for the proper function of all cells, tissues, and organs in the human body found abundantly in Swiss Chard, Lima Beans, Potatoes, Yam, Soybeans and all meats and fish, etc.
Potassium and Gastrointestinal (GI) functional and motility disorders
Gastrointestinal (GI) functional and motility disorders are highly prevalent and responsible for long-term morbidity and sometimes mortality in the affected patients. It is estimated that one in three persons has a GI functional or motility disorder. Voltage-sensitive ion channels (VSICs) have significant structural homology and common functional mechanisms and are potential targets for intervention in GI motility disorders. We describe the constituent VSICs, which include voltage-gated sodium (Na(V)), calcium (Ca(V)), potassium (K(V), K(Ca)), chloride (Cl(-)) and nonselective ion channels (transient receptor potentials [TRPs]).and outline the approaches and limitations and provide examples of targeting VSICs at the pores, voltage sensors and alternatively spliced sites. Rational drug design can come from an integrated view of the structure and mechanisms of gating and activation by voltage or mechanical stress(6).
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Sources
(6) http://www.ncbi.nlm.nih.gov/pubmed/22282704
http://medicaladvisorjournals.blogspot.com
2012-11-26 11:20:19
Source: http://medicaladvisorjournals.blogspot.com/2012/11/potassium-and-gastrointestinal-gi.html
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