What is the importance of AxioMx?

Main objective of antibody screening

AxioMx is applying knowledge for the past 15 years of human genome sequencing to produce highly specific recombinant antibodies against the human proteome. The antibody development paradigm is too slow and does not always result in consistent, renewable and quality antibodies. AxioMax believe in platform which will lead to the wide adoption of recombinant antibody use in research and diagnostic applications. AxioMx offers custom recombinant antibody recovery and development services ranging from peptide synthesis to large scale antibody production.

• They enable fast delivery of highly specicifc
• high affinity
• highly reproducible recombinant monoclonal antibodies that are optimized to work in desired applications

Monoclonal antibody is a laboratory produced molecule that is carefully engineered to attach to specific defects in cancer cells. NHL is a serious affection which occurs due to the presence of B cells, a type of white blood cells which lead to severe complications such as tumors. Monoclonal antibody has been found safe and effective method for certain patients. This type of monoclonal antibody drugs are relatively a new innovation in cancer treatment. Monoclonal antibodies have been produced in laboratories like many other antibodies and have the role in producing anti-tumor effects. The treatment with monoclonal antibody has bought results in healing lymphoma. Monoclonal antibody therapy is the use of monoclonal antibodies to specifically bind to target cells or proteins.

Antibody screening is the method of determining the presence and amount of anti-HLA antibodies in the serum of a potential allograft. The antibody screening consists of testing the recipient serum or plasma against two or three screening cells. The main goal of antibody screening is to detect unexpected clinically significant red cell antibodies. These antibodies are called unexpected because only 0.3 to 2% of the general population have positive antibody screen.

Phage display is a laboratory technique for the study of protein- protein, protein- peptide and protein-DNA interactions that uses bacteriophages to connect proteins with the genetic information that encodes them. Phage display can be simply explained as the process of displaying peptides or proteins on the surface of bacteriophages. Phage display was first explained by George P Smith in 1985. Phage display can be used for the selection of proteins, peptides or antibodies with affinity and specificity to a molecule or protein. It can also be helpful for preservation of unstable hybridoma clones and to identify molecules that can be recognized. The main purpose of phase display is to determine proteins that will interact with disease causing molecules with the intent of disarming these molecules and curing or weakening the disease.

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