Association Between Markers of Obesity and Progression From Barrett's Esophagus to Esophageal Adenocarcinoma

Home of Kyle J. Norton for The Better of Living & Living Health Obesity is defined as a medical condition of excess body fat has accumulated overtime, while overweight is a condition of excess body weight relatively to the height. According to the Body Mass Index(BMI), a BMI between 25 to 29.9 is considered over weight, while a BMI of over 30 is an indication of obesity. According to the statistic, 68% of American population are either overweight or obese. Clinically Overweight and obesity are defined indicators of a disease process characterized by the accumulation of body fat due to an excess of energy intake (nutritional intake) relative to energy expenditure (physical activity)(a).
Esophageal cancer
Espophagus or gullet, an organ in vertebrates, is the tube that lead foods from the pharynx to the stomach. Esophageal cancer is not very uncommon and caused by malignant of the esophagus due to abnormal cell growth as a result of the DNA alternation of the cells that line the upper part of the esophagus or glandular cells that are present at the lower part of the esophagus that connected with the stomach. The esophageal cancer tends to spread if it left untreated and starts from the lining of esophagus, then later penetrate in the the wall of the esophagus and spread to the lumph node around the bottom of the esophagus, stomach and the chest, then to the distant parts of the body. 
Association Between Markers of Obesity and Progression From Barrett’s Esophagus to Esophageal Adenocarcinoma
Individuals with Barrett’s esophagus (BE) have an increased risk of developing esophageal adenocarcinoma (EA). Obesity contributes to the development of BE and its progression to cancer.  In the study to investigate the roles of obesity-induced hyperinsulinemia and dysregulation of adipokines in these processes, showed that among patients with BE, increased levels of leptin and insulin resistance are associated with increased risk for EA, whereas increased levels of high-molecular-weight adiponectin is associated inversely with EA. These biomarkers might be used to determine cancer risk among patients with BE(3).
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Sources
(a) http://www.ncbi.nlm.nih.gov/pubmed/19107429  
(3) http://www.ncbi.nlm.nih.gov/pubmed/23466711   http://medicaladvisorjournals.blogspot.com