GMOs - Nitroreductase-mediated gonadal dysgenesis for infertility control of genetically modified zebrafish

Home of Kyle J. Norton for The Better of Living & Living Health Health risk assessment of genetically modified organisms (GMOs) cultivated for food or feed is under debate throughout the world, and very little data have been published on mid- or long-term toxicological studies with mammals.
The Con’s of GMOs include consumer and health groups, grain importers from European Union (EU) countries, organic farmers, environmentalists, concerned scientists, ethicist, religious rights groups, food advocacy groups, some politicians and trade protectionists
The Pro’s of GMOs include private industries, research scientists, some consumers, U.S. farmers and regulatory agencies.
Here are some of their studies, please make sure you understand the intention of their differentiation.
Nitroreductase-mediated gonadal dysgenesis for infertility control of genetically modified zebrafish
Genetically modified (GM) fish with desirable features such as rapid growth, disease resistance, and cold tolerance, among other traits, have been established in aquaculture. However, commercially available GM fish are restricted because of global concerns over the incomplete assessments of food safety and ecological impact. According to the study by the Institute of Cellular and Organismic Biology, Academia Sinica, in the study with zebrafish was used as a model to establish an inducible platform of infertility control in GM fish, showed that oocyte-specific nitroreductase-mediated catalysis of metronidazole blocks oogenesis and leads to an undeveloped oocyte. Furthermore, oocyte cell death via apoptosis was detected by a TUNEL assay. We found that the gonadal dysgenesis induced by metronidazole resulted in activation of the ovarian killer gene bok, which is a proapoptotic gene member of the Bcl-2 family and led to infertility. These results show that oocyte-specific nitroreductase-mediated catalysis of metronidazole can cause reliable infertility in zebrafish and could potentially be used as a model for other aquaculture fish species(31).
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Sources
(31) http://www.ncbi.nlm.nih.gov/pubmed/19941022  http://medicaladvisorjournals.blogspot.com