Read the Beforeitsnews.com story here. Advertise at Before It's News here.

By Renal Fellow Network (Reporter)
Contributor profile | More stories

Story Views
Now:
Last hour:
Last 24 hours:
Total:

Pulsating glomeruli

Monday, June 24, 2013 15:57

% of readers think this story is Fact. Add your two cents.

It seems incredible now that it was only in 1998 that it was conclusively proven that the podocyte plays a vital role in the prevention of albuminuria. At that time mutations in NPHS1, encoding nephrin, were found in 49 patients from Finland with congenital nephrotic syndrome. Up to that point, the podocyte was thought to play a secondary role in the glomerular filtration barrier. Since then, multiple mutations in different podocyte proteins have been identified in association with proteinuria. The table below (taken from a recent Nature Reviews Nephrology article) summarizes the podocyte-related genes that have been associated with albuminuria (click to enlarge).

Orthodoxies continue to be challenged – the old model of podocytes that are fixed in place is being replaced by one where podocytes are constantly moving, being shed and replaced. The video below is from a remarkable paper where the authors have used GFP to visualize podocytes in mouse glomeruli. The pulsatile nature of glomerular contractions is notable and fascinating.

Source: http://renalfellow.blogspot.com/2013/06/pulsating-glomeruli.html

Before It’s News® is a community of individuals who report on what’s going on around them, from all around the world.

Anyone can join.
Anyone can contribute.
Anyone can become informed about their world.

"United We Stand" Click Here To Create Your Personal Citizen Journalist Account Today, Be Sure To Invite Your Friends.

Please Help Support BeforeitsNews by trying our Natural Health Products below!

Order by Phone at 888-809-8385 or online at https://mitocopper.com M - F 9am to 5pm EST

Order by Phone at 866-388-7003 or online at https://www.herbanomic.com M - F 9am to 5pm EST

Order by Phone at 866-388-7003 or online at https://www.herbanomics.com M - F 9am to 5pm EST

Humic & Fulvic Trace Minerals Complex - Nature's most important supplement! Vivid Dreams again!

HNEX HydroNano EXtracellular Water - Improve immune system health and reduce inflammation.

Ultimate Clinical Potency Curcumin - Natural pain relief, reduce inflammation and so much more.

MitoCopper - Bioavailable Copper destroys pathogens and gives you more energy. (See Blood Video)

Oxy Powder - Natural Colon Cleanser! Cleans out toxic buildup with oxygen!

Nascent Iodine - Promotes detoxification, mental focus and thyroid health.

Smart Meter Cover - Reduces Smart Meter radiation by 96%! (See Video).

Comments

Online:
Visits:	1,605,887,150
Stories:	8,157,519