Cycle and hormone changes during perimenopause: the key role of ovarian function

Home of Kyle J. Norton for The Better of Living & Living Health  Antimullerian hormone also known  AMH is a protein that, in humans, encoded by the AMH gene. It inhibits the development of the Müllerian ducts (paramesonephric ducts) in the male embryo(a).
Cycle and hormone changes during perimenopause: the key role of ovarian function
The menopausal transition is the stage in reproductive life commonly defined as commencing with the onset of menstrual irregularity, showed that there is no endocrine marker of menopause, which may be primarily an endometrial event. Using the hormonal concentrations in ovulatory cycles observed in women in mid-reproductive age as controls and comparing such concentrations in late reproductive age women older than 45 either continuing to cycle regularly or having entered the early or late menopausal transition, a gradual increase in follicular phase FSH and E2 and a decrease in inhibin B were observed in ovulatory cycles. Anovulatory cycles showed markedly increased FSH with low E2 and inhibin B. No specific endocrine change was characteristic of either the early or late menopausal transition, confirming the observations of previous studies regarding the unpredictability of cycle characteristics and hormone changes with the approach of menopause. Antimüllerian hormone correlates with follicle numbers and shows a large age-related decrease to reach undetectable levels at menopause. Thus, the marked decrease in follicle numbers during late reproductive age appears to predispose to erratic and unpredictable cycle characteristics, with normal ovulatory cycles continuing to occur episodically. There is no specific endocrine marker of the early or late transition, making measurements of FSH or E2 unreliable in attempting to stage an individual with regard to approaching menopause(5).
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Sources
(a) http://en.wikipedia.org/wiki/Antimullerian_hormone
(5) http://www.ncbi.nlm.nih.gov/pubmed/18574431 http://medicaladvisorjournals.blogspot.com