Increased polyamine intake inhibits age-associated alteration in global DNA methylation and 1,2-dimethylhydrazine-induced tumorigenesis

Home of Kyle J. Norton for The Better of Living & Living Health Human aging is a biological process, no one can stop, but delay it. It is possible that one person looks younger than his or her biological if one engages in healthy living life style and eating healthily by increasing the intake of good healthy food such as whole grain, fruits, vegetables, beans and legumes, etc. and reducing the consumption of harmful foods, such as saturated fat, trans fat, artificial ingredients, etc.
Spermidine is a naturally occurring polyamine involved in multiple biological processes, including DNA metabolism, autophagy and aging.
Increased polyamine intake inhibits age-associated alteration in global DNA methylation and 1,2-dimethylhydrazine-induced tumorigenesis
Polyamines (spermine and spermidine) play many important roles in cellular function and are supplied from the intestinal lumen. The study by the  Jichi Medical University, showed that of twenty-four week old Jc1:ICR male mice were fed one of three experimental chows containing different polyamine concentration. Lifetime intake of high polyamine chow, which had a polyamine content approximately three times higher than regular chow, elevated polyamine concentrations in whole blood, suppressed age-associated increases in pro-inflammatory status, decreased age-associated pathological changes, inhibited age-associated global alteration in DNA methylation status and reduced the mortality in aged mice. Exogenous spermine augmented DNA methyltransferase activity in Jurkat and HT-29 cells and inhibited polyamine deficiency-induced global alteration in DNA methylation status in vitro. In addition, increased polyamine intake was associated with a decreased incidence of colon tumors in BALB/c mice after 1,2-demethylhydrazine administration; 12 mice (60%) in the low polyamine group developed tumors, compared with only 5 mice (25%) in the high polyamine group (Fisher’s exact probability = 0.027, p = 0.025). However, increased polyamine intake accelerated the growth of established tumors; maximal tumor diameter in the Low and High groups was 3.85±0.90 mm and 5.50±1.93 mm, respectively (Mann-Whitney test, p = 0.039). Spermine seems to play important roles in inhibiting age-associated and polyamine-deficient induced abnormal gene methylation as well as pathological changes including tumorigenesis(16).
For Women Who Want to Look 5 -7 Years Younger  
The Beauty of Foods – Utilizing the Use of Foods to Look 
Years Younger Naturally such as Remedies 4 Botox Replacement….

For the series of anti-Aging  Article visit http://medicaladvisorjournals.blogspot.ca/p/anti-aging-naturally.html

For other health article, visit http://medicaladvisorjournals.blogspot.ca    
Sources
(16) http://www.ncbi.nlm.nih.gov/pubmed/23696883  http://medicaladvisorjournals.blogspot.com