Loss of LH-induced down-regulation of anti-Mullerian hormone receptor expressionand the anovulation in women with polycystic ovary syndrome.

Home of Kyle J. Norton for The Better of Living & Living Health Antimullerian hormone also known  AMH is a protein that, in humans, encoded by the AMH gene. It inhibits the development of the Müllerian ducts (paramesonephric ducts) in the male embryo(a).
Loss of LH-induced down-regulation of anti-Mullerian hormone receptor expressionand the anovulation in women with polycystic ovary syndrome
In the study of anti-Müllerian hormone (AMH) and AMH type II receptor (AMHR-II) mRNAs similarly regulated by gonadotrophins in lutein granulosa cells (GCs) from control, normo-ovulatory and oligo/anovulatory women with polycystic ovary syndrome (PCOS), found that
the lutein GCs are not the best model to study AMH and AMHR-II regulation by gonadotrophins. Indeed, AMH and AMHR-II are down-regulated in luteinized cells. Furthermore, these cells have been exposed to non-physiological levels of gonadotrophins and hCG. However, AMH and AMHR-II mRNAs are quantifiable by real-time RT-PCR, and the cells are still responsive to FSH and LH. The age of patients is significantly different between control and oligo/anovulatory PCOS women: this may be a bias in the interpretation of results but older women in the control group had a good ovarian reserve. The overexpression of AMH and AMHR-II in oligo/anovulatory PCOS women could be due to increased LH levels and/or inhibition of its repressive action. The fact that this dysregulation is observed in oligo/anovulatory, but not in normo-ovulatory, PCOS women emphasizes the role of LH in the follicular arrest of PCOS women and suggests that this involves the AMH/AMHR-II system(2).
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Sources
(a) http://en.wikipedia.org/wiki/Antimullerian_hormone   
(2) http://www.ncbi.nlm.nih.gov/pubmed/23321213  http://medicaladvisorjournals.blogspot.com