SOGC Clinical Practice Guideline. Magnesium sulphate for fetal neuroprotection
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Magnesium is the eleventh most abundant element by mass in the human body. The adult body content is 25 g distributed in the skeleton and soft tissues. The chemical is essential in manipulating important biological polyphosphate such as ATP, DNA, and RNA and in functionming enzymes(a).
SOGC Clinical Practice Guideline. Magnesium sulphate for fetal neuroprotection
In the study to provide guidelines for the use of antenatal magnesium sulphate (MgSO4) for fetal neuroprotection of the preterm infant, indicated that antenatal magnesium sulphate for fetal neuroprotection reduces the risk of “death or CP” (RR 0.85; 95% CI 0.74 to 0.98; 4 trials, 4446 infants), “death or moderate-severe CP” (RR 0.85; 95% CI 0.73 to 0.99; 3 trials, 4250 infants), “any CP” (RR 0.71; 95% CI 0.55 to 0.91; 4, trials, 4446 infants), “moderate-to-severe CP” (RR 0.60; 95% CI 0.43 to 0.84; 3 trials, 4250 infants), and “substantial gross motor dysfunction” (inability to walk without assistance) (RR 0.60; 95% CI 0.43 to 0.83; 3 trials, 4287 women) at 2 years of age. Results were consistent between trials and across the meta-analyses. There is no anticipated significant increase in health care-related costs, because women eligible to receive antenatal MgSO4 will be judged to have imminent preterm birth(8).
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Sources
(a) http://en.wikipedia.org/wiki/Magnesium
(8) http://www.ncbi.nlm.nih.gov/pubmed/21639972 http://medicaladvisorjournals.blogspot.com
Source: http://medicaladvisorjournals.blogspot.com/2013/08/sogc-clinical-practice-guideline.html
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