Spermidine inhibits MMP-2 via modulation of histone acetyltransferase and histone deacetylase in HDFs

Home of Kyle J. Norton for The Better of Living & Living Health Human aging is a biological process, no one can stop, but delay it. It is possible that one person looks younger than his or her biological if one engages in healthy living life style and eating healthily by increasing the intake of good healthy food such as whole grain, fruits, vegetables, beans and legumes, etc. and reducing the consumption of harmful foods, such as saturated fat, trans fat, artificial ingredients, etc.
Spermidine is a naturally occurring polyamine involved in multiple biological processes, including DNA metabolism, autophagy and aging.
Spermidine inhibits MMP-2 via modulation of histone acetyltransferase and histone deacetylase in HDFs
In recent years, aging has been reported to be regulated by HAT. In the study to assess the inhibitory effects of spermidine on the matrix metalloproteinase-2 (MMP-2) activity and expression were investigated in human dermal fibroblasts (HDFs), showed that spermidine inhibits MMP-2 activity and expression. In addition, the expression levels of histone acetyltransferase (HAT), phospho-extracellular-signal related kinase (p-ERK), phospho-c-jun N-terminal kinase (p-JNK), and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB) are decreased in the presence of spermidine. In contrast, the expression levels of histone deacetylase 1 (HDAC1), sirtuin 1 (SIRT1), phospho-p38 (p-p38) are increased by spermidine and suggested that spermidine could have a therapeutic potential in inhibition of metastasis through the inhibitory effects on activity and expression of MMP-2 via regulation of HAT and HDAC(4).

For Women Who Want to Look 5 -7 Years Younger  
The Beauty of Foods – Utilizing the Use of Foods to Look 
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Sources
(4) http://www.ncbi.nlm.nih.gov/pubmed/22925630  http://medicaladvisorjournals.blogspot.com