Adipokines mediate inflammation and insulin resistance
Home of Kyle J. Norton for The Better of Living & Living Health Adiponectin
A protein hormone encoded by the ADIPOQ gene and produced and secreted exclusively by adipocytes with the function of of regulating the metabolism of lipids and glucose(a)(b).
Adipokines mediate inflammation and insulin resistance
According to the study by the Albert Einstein College of Medicine, these adipokines function as classic circulating hormones to communicate with other organs including brain, liver, muscle, the immune system, and adipose tissue itself. The dysregulation of adipokines has been implicated in obesity, type 2 diabetes, and cardiovascular disease. Recently, inflammatory responses in adipose tissue have been shown as a major mechanism to induce peripheral tissue insulin resistance. Although leptin and adiponectin regulate feeding behavior and energy expenditure, these adipokines are also involved in the regulation of inflammatory responses. Adipose tissue secretes various pro- and anti-inflammatory adipokines to modulate inflammation and insulin resistance. In obese humans and rodent models, the expression of pro-inflammatory adipokines is enhanced to induce insulin resistance. Collectively, these findings have suggested that obesity-induced insulin resistance may result, at least in part, from an imbalance in the expression of pro- and anti-inflammatory adipokines(6).
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Sources
(a) http://www.medterms.com/script/main/art.asp?articlekey=17982
(b) http://en.wikipedia.org/wiki/Adiponectin
(6) http://www.ncbi.nlm.nih.gov/pubmed/23781214 http://medicaladvisorjournals.blogspot.com
Source: http://medicaladvisorjournals.blogspot.com/2013/09/adipokines-mediate-inflammation-and.html
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