Altered expression of C/EBP family members results in decreased adipogenesis with aging

Home of Kyle J. Norton for The Better of Living & Living Health Adiponectin
A protein hormone encoded by the ADIPOQ gene and produced and secreted exclusively by adipocytes with the function of of  regulating the metabolism of lipids and glucose(a)(b).
Altered expression of C/EBP family members results in decreased adipogenesis with aging
According to the study by the Boston University, overexpression of C/EBP alpha in preadipocytes cultured from old rats restored capacity to differentiate into fat cells, indicating that downstream differentiation-dependent genes maintain responsiveness to regulators of adipogenesis. C/EBP alpha-expression also decreased with age in fat tissue from three different depots and in isolated fat cells. The overall level of C/EBP beta, which modulates C/EBP alpha-expression, did not change with age, but the truncated, dominant-negative C/EBP beta-liver inhibitory protein (LIP) isoform increased in cultured preadipocytes and isolated fat cells. Overexpression of C/EBP beta-LIP in preadipocytes from young rats impaired adipogenesis. C/EBP delta, which acts with full-length C/EBP beta to enhance adipogenesis, decreased with age. Thus processes intrinsic to adipose cells involving changes in C/EBP family members contribute to impaired adipogenesis and altered fat tissue function with aging. These effects are potentially reversible(9).

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Sources
(a) http://www.medterms.com/script/main/art.asp?articlekey=17982 
(b) http://en.wikipedia.org/wiki/Adiponectin   
(9) http://www.ncbi.nlm.nih.gov/pubmed/11353682  http://medicaladvisorjournals.blogspot.com