Comparison of salbutamol with normal saline and salbutamol with magnesium sulphate in the treatment of severe acute asthma
Home of Kyle J. Norton for The Better of Living & Living Health Magnesium is the eleventh most abundant element by mass in the human body. The adult body content is 25 g distributed in the skeleton and soft tissues. The chemical is essential in manipulating important biological polyphosphate such as ATP, DNA, and RNA and in functionming enzymes(a).
Comparison of salbutamol with normal saline and salbutamol with magnesium sulphate in the treatment of severe acute asthma
In the study to compare the efficacy and safety of nebulized magnesium sulphate with salbutamol to normal saline with salbutamol as the initial treatment of severe acute asthma patients, designed as a randomized open controlled clinical trial. The study was conducted Mymensingh Medical College Hospital over a period of 11 months from December 2009 to October 2010, showed that peak flow at baseline was similar in two groups. At 10 minutes after nebulization, the mean±SD percentage increase in peak flow was greater in magnesium sulphate group (20±4%) than in the normal saline salbutamol group (13±3%). At 20 minutes the percentage increase in peak flow was greater in magnesium sulphate group (35±7%) than in the normal saline salbutamol group (24±6%) p value <0.001. Magnesium sulphate plus salbutamol group reached PEF near to 60% which is not in saline salbutamol group. There was no significant changed in respiratory rate, pulse rate, systolic, diastolic blood pressure and clinical evidence of unwanted adverse effect(10).
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Sources
(a) http://en.wikipedia.org/wiki/Magnesium
(10) http://www.ncbi.nlm.nih.gov/pubmed/23416800 http://medicaladvisorjournals.blogspot.com
Source: http://medicaladvisorjournals.blogspot.com/2013/09/comparison-of-salbutamol-with-normal.html
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