Elevated adiponectin expression promotes adipose tissue vascularity under conditions of diet-induced obesity
Home of Kyle J. Norton for The Better of Living & Living Health Adiponectin
A protein hormone encoded by the ADIPOQ gene and produced and secreted exclusively by adipocytes with the function of of regulating the metabolism of lipids and glucose(a)(b).
Elevated adiponectin expression promotes adipose tissue vascularity under conditions of diet-induced obesity
In the study to investigate the wild type, adiponectin-deficient, and adiponectin transgenic-overexpressing mice were maintained on chow diet or high fat/high sucrose diet for 32weeks, showed that Adiponectin over-expression in diet-induced obese mice also led to the virtual absence of macrophage infiltration and the elimination of crown-like structures. Adiponectin transgenic mice also displayed a remarkable sensitivity to insulin and diminished hepatic steatosis. These data demonstrate that increased circulating adiponectin levels, and the obese environment, are associated with increased adipose tissue vascularization and perfusion, and improved metabolic function under conditions of long term diet-induced obesity(1).
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Sources
(a) http://www.medterms.com/script/main/art.asp?articlekey=17982
(b) http://en.wikipedia.org/wiki/Adiponectin
(1) http://www.ncbi.nlm.nih.gov/pubmed/23993424 http://medicaladvisorjournals.blogspot.com
Source: http://medicaladvisorjournals.blogspot.com/2013/09/adiponectin-protein-hormone-encoded-by.html
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