Stress-induced corticotropin-releasing hormone-mediated NLRP6 inflammasome inhibition and transmissible enteritis

Home of Kyle J. Norton for The Better of Living & Living Health Adrenocorticotropic hormone (ACTH) or corticotropin, is a  hormone produced by the anterior pituitary gland in response to biological stress by effecting the increased production and release of corticosteroids(a)
Stress-induced corticotropin-releasing hormone-mediated NLRP6 inflammasome inhibition and transmissible enteritis
Stress alters brain-gut interactions and could exacerbate intestinal disorders, including irritable bowel syndrome. Alterations in the intestinal microbiota have been associated with irritable bowel syndrome.
In the study to mice that were not exposed to stress were co-housed with mice subjected to WAS to determine the effects of WAS-induced dysbiosis, measured by sequencing bacterial 16S ribosomal RNA. We also assessed the effects of a peroxisome proliferator-activated receptor-γ agonist and probiotics, found that mice expose to stress inhibits NLRP6 and alters the composition of the gut microbiota, leading to intestinal inflammation. These findings might explain the benefits of probiotics for patients with stress-associated gastrointestinal disorders(1).
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Sources
(a) http://en.wikipedia.org/wiki/Adrenocorticotropic_hormone
(1) http://www.ncbi.nlm.nih.gov/pubmed/23470617  http://medicaladvisorjournals.blogspot.com