Anti-angiogenic effects of epigallocatechin-3-gallate in human skin
Home of Kyle J. Norton for The Better of Living & Living Health Green tea contains more amount of antioxidants than any drinks or food with the same volume, and is the leaves of Camellia sinensis, undergone minimal oxidation during processing, originated from China. Green tea has been a precious drink in traditional Chinese culture and used exceptional in socialization for more than 4000 thousand years. Because of their health benefits, they have been cultivated for commercial purposes all over the world.
Anti-angiogenic effects of epigallocatechin-3-gallate in human skinIn a small randomized, double blind, split face trial using a cream containing 2.5% w/w of EGCG of four healthy volunteers with significant erythema and telangiectasia on the face applied EGCG cream to one side of the face, and vehicle control cream to the other, twice daily for six weeks, found that HIF-1 α expression was decreased in EGCG treated sites, such that 28.4% of the epidermis showed positive staining in vehicle treated vs. 13.8% in EGCG treated sites (p<0.001). A similar decrease in VEGF expression was found (6.7% in EGCG vs. 11.0%in in vehicle-treated skin (p<0.005). EGCG topical treatments influence HIF-1 α induction and VEGF expression and may serve as a potential agent in the prevention of telangiectasias(19).
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(19) http://www.ncbi.nlm.nih.gov/pubmed/20830241
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Source: http://medicaladvisorjournals.blogspot.com/2013/10/anti-angiogenic-effects-of.html
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