Testicular adrenal rest "tumor" or Leydig cell tumor
Testicular adrenal rest “tumor” or Leydig cell tumor
There is a report of a case of mass-forming TART and we discuss the clinical, radiological, and morphological features as well as the major differential diagnosis of this rare lesion. Testicular adrenal rest tumors (TARTs) are an important complication of CAH, which probably develop from ectopic remnants of intra-testicular adrenal tissue stimulated by Adrenocorticotropic hormone (ACTH) hypersecretion. These lesions are typically located within the rete testis and are bilateral, synchronous, nodular and multiple. TART usually, but not always, responses to suppressive medical therapy. TART leads to testicular structural damage, spermatogenesis disorders, infertility and most importantly, mass-forming lesions that could be mistaken for Leydig cell tumor (LCT). The later has a significantly different behavior with up to 10% of being malignant. Nowadays, due to advances in diagnosing and treating CAH, mass-forming TART is rarely encountered(25).
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Sources
(a) http://en.wikipedia.org/wiki/Adrenocorticotropic_hormone
(25) http://www.ncbi.nlm.nih.gov/pubmed/23984262
Source: http://medicaladvisorjournals.blogspot.com/2013/10/testicular-adrenal-rest-tumor-or-leydig.html
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