Holistic approach for Prevention, controlling and Treatment of Candida Albicans Overgrowth- The Effectiveness of Minerals and Mineral Compounds

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By Kyle J. Norton Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it’s news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada – Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

What is Candida Albicans
Candida albicans are members of a large group of micro organism whose cells contain complex structures enclosed within the membranes, including yeast(2)(3), fungi(4)(5)(6), and mold(6) that live among the gut flora in the human mouth and gastrointestinal tract. In fact, under normal circumstances, Candida albicans that does not cause harmful effects, but overgrowth results in candidiasis. Non-albicans Candida (NAC) species cause 35-65% of all candidaemias in the general patient population(1). According to joint study, in many cases, biofilm(microorganisms with cells stick to each other on a surface) formation(7) gene mutations(8) and overexpression of genes(9)(10) are often associated with increased Candida resistance toward antifungal agents.

Treatments and controllings
C. Minerals and mineral compounds1. Coral Calcium
One of the richest sources of Calcium not only is an important mineral in building stronger, denser bones early in life and keeping bones strong(248) and healthy later in life and preventing the risk of osterporosis(249), but also helps to alkalize the body that eliminate the favor environment for candida overgrowth(250).

2. Magnesium Citrate
Magnesium Citrate is a magnesium salt of citric acid, is a chemical agent used medicinally as a saline laxative(251). Beside it is important to maintain proper level of pH(252) for the body’s organs to enhance their biochemical pathways for detoxification(253), that limits or reduces the over growth of candida, it also acts as a defecation in stimulating naturally bowel movement.
The mineral, magnesium plays a key role in the immune response, by acting as a co-factor for immunoglobulin synthesis(254) that significantly increases for both IgA and IgG, the antibody molecules that protect our body against bacterial and viral infections(255) and the lining of the respiratory passages, gastrointestinal and genitourinary tract(255).

3. Lithium chloride
Lithium chloride is a chemical compound with the formula LiCl. The salt is a typical ionic compound. While maintaining the proper PH levels(257), lithium also suppresses the yeast phosphoglucomutase activity(256) and inhibits the candida albicans filamentation and hyphal outgrowth(258).

4. Sodium bicarbonate
Used as an alkaline treatment(259), sodium bicarbonate is important to balance the levels of PH by taking away the acidity environment for candida overgrowth(260)(261). Researchers  found that 5% sodium bicarbonate on the adherence of Candida albicans to thermally activated acrylic resin proved to be a viable alternative in the reduction of Candida albicans(262).

5. Phosphonium salts
Phosphonium salts with long alkyl chains (C18) were found to show high levels of antimicrobial activity(263). In the alkyltrimethylphosphonium salts(263), the bactericidal activity against S. aureus and Escherichia coli increased with increasing alkyl chain length(263), probably through its antimicrobial polymers(264), according to the joint study by University of New Brunswick, Southwest Petroleum University, and North China Electric Power University

6. Zinc
Zinc besides is an important mineral in boosting immune system activity(265)(266), its nano-structure zinc(II) coordination compounds also used in zinc therapy to treat candida overgrowth(267) by promoting metallothionein (MT)(found in high concentration in intestinal mucosa)synthesis(268) through its anti inflammatory activity(269).

7. Etc

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+ References
(1) Non-albicans Candida spp. causing fungaemia: pathogenicity and antifungal resistance by Krcmery V¹, Barnes AJ.(PubMed)
(2) Pathogenicity and drug resistance in Candida albicans and other yeast species. A review by Mishra NN¹, Prasad T, Sharma N, Payasi A, Prasad R, Gupta DK, Singh R.(PubMed)
(3)  Multidrug resistance in yeast Candida by Prasad R¹, Kapoor K.(PubMerd)
(4) New evidence that Candida albicans possesses additional ATP-binding cassette MDR-like genes: implications for antifungal azole resistance. by Walsh TJ¹, Kasai M, Francesconi A, Landsman D, Chanock SJ.(PubMed)
(5) Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters.by Sanglard D¹, Kuchler K, Ischer F, Pagani JL, Monod M, Bille J.(PubMed)
(6) Structural analysis of phospho-D-mannan-protein complexes isolated from yeast and mold form cells of Candida albicans NIH A-207 serotype A strain by Shibata N¹, Fukasawa S, Kobayashi H, Tojo M, Yonezu T, Ambo A, Ohkubo Y, Suzuki S.(PubMed)
(7) The effect of antifungal combination on transcripts of a subset of drug-resistance genes in clinical isolates of Candida species induced biofilms by Ibrahim NH¹, Melake NA², Somily AM³, Zakaria AS⁴, Baddour MM⁵, Mahmoud AZ⁶(PubMed)
(8) Antifungal drug resistance in pathogenic fungi. by Vanden Bossche H¹, Dromer F, Improvisi I, Lozano-Chiu M, Rex JH, Sanglard D.(PubMed)
(9) The genetic basis of fluconazole resistance development in Candida albicans by Morschhäuser J¹.(PubMed)
(10) A proteomic approach to understanding the development of multidrug-resistant Candida albicans strains by Kusch H¹, Biswas K, Schwanfelder S, Engelmann S, Rogers PD, Hecker M, Morschhäuser J.(PubMed)
 

(264) Antimicrobial Polymeric Materials with Quaternary Ammonium and Phosphonium Salts by Xue Y1,2, Xiao H3, Zhang Y4.(PubMed)
(265) Zinc and the immune system by Rink L1, Gabriel P.(PubMed)
(266) The immune system and the impact of zinc during aging by Haase H1, Rink L.(PubMed)
(267) Some new nano-structure zinc(II) coordination compounds of an imidazolidine Schiff base: spectral, thermal, antimicrobial properties and DNA interaction. Montazerozohori M1, Musavi SA2, Naghiha A3, Zohour MM4.(PubMed)
(268) Candida article zinc and metallothionein(Cure zone)
(269) Metallothionein as an Anti-Inflammatory Mediator(Mediators of inflammation)