Anti-Cancer Properties Found in Spicy Indian Pepper Plant
The secret lies in a chemical called Piperlongumine (PL), which has shown activity against many cancers including prostate, breast, lung, colon, lymphoma, leukemia, primary brain tumors, and gastric cancer.
Using x-ray crystallography, researchers were able to create molecular structures that show how the chemical is transformed after being ingested. PL converts to hPL, an active drug that silences a gene called GSTP1. The GSTP1 gene produces a detoxification enzyme that is often overly abundant in tumors.
The long pepper, a plant native to India, is found in southern India and southeast Asia. Although rare in European fare, it is commonly found in Indian stores and used as a spice or seasoning in stews and other dishes. It dates back thousands of years in the Indian subcontinent tied to Ayurveda, one of the world’s oldest medical systems, and was referred to by Hippocrates, the ancient Greek physician known as the father of medicine.
Dr. Westover’s lab used X-ray crystallography to create this molecular model of piperlongumine.
The study is published in the Journal of Biological Chemistry.
This work is supported by the V Foundation for Cancer Research, founded by ESPN and legendary basketball coach Jim Valvano, The Welch Foundation, and the Cancer Prevention and Research Institute of Texas.
Additional UT Southwestern researchers who contributed to the study include alumni of the Westover lab: Dr. Wayne Harshbarger, Dr. John Hunter and Dr. Durga Udayakumar. Current UT Southwestern scientists in the Departments of Radiation Oncology and Biochemistry include Dr. Deepak Gurbani, Dr. William Singer, Dr. Yan Liu, Dr. Lianbo Li and Dr. Sudershan Gondi.
The Harold C. Simmons Comprehensive Cancer Center is the only NCI-designated Comprehensive Cancer Center in North Texas and one of just 47 NCI-designated Comprehensive Cancer Centers in the nation. Simmons Cancer Center includes 13 major cancer care programs. In addition, the Center’s education and training programs support and develop the next generation of cancer researchers and clinicians. Simmons Cancer Center is among only 30 U.S. cancer research centers to be designated by the NCI as a National Clinical Trials Network Lead Academic Participating Site.
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UT Southwestern Medical Center
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