Daily Ibuprofen Wards Off Alzheimer's Disease Says Canadian Researcher
The means are now at hand to conquer Alzheimer’s disease (AD). Dr. Patrick McGeer, has successfully carried out studies suggesting that, if started early enough, a daily regimen of the non-prescription NSAID ibuprofen can prevent the onset of Alzheimer’s diseas
A Vancouver-based research team led by Canada’s most cited neuroscientist, Dr. Patrick McGeer, has successfully carried out studies suggesting that, if started early enough, a daily regimen of the non-prescription NSAID (nonsteroidal anti-inflammatory drug) ibuprofen can prevent the onset of Alzheimer’s disease. This means that by taking an over-the-counter medication, people can ward off a disease that, according to Alzheimer’s Disease International’s World Alzheimer Report 2016, affects an estimated 47 million people worldwide, costs health care systems worldwide more than US$818 billion (1) per year and is the fifth leading cause of death in those aged 65 or older.
This is Patrick L. McGeer, M.D., Ph.D.
Credit: Kinsmen Lab. of Neurological Research
Dr. McGeer, who is President and CEO of Vancouver-based Aurin Biotech, and his wife, Dr. Edith McGeer, are among the most cited neuroscientists in the world. Their laboratory is world-renowned for their 30 years of work in neuroinflammation and neurodegenerative diseases, particularly Alzheimer’s disease. A paper detailing Dr. McGeer’s most recent discoveries were published Friday in the prestigious Journal of Alzheimer’s Disease. (Journal of Alzheimer’s Disease 62 (pp. 1219-1222).
In 2016, Dr. McGeer and his team announced that they had developed a simple saliva test that can diagnose Alzheimer’s disease, as well as predict its future onset. The test is based on measuring the concentration of the peptide amyloid beta protein 42 (Abeta42) secreted in saliva. In most individuals, the rate of Abeta 42 production is almost exactly the same regardless of sex or age. However, if that rate of production is two to three times higher, those individuals are destined to develop Alzheimer’s disease. That is because Abeta42 is a relatively insoluble material, and although it is made everywhere in the body, deposits of it occur only in the brain, causing neuroinflammation, which destroys neurons in the brains of people with Alzheimer’s disease.
Contrary to the widely held belief that Abeta 42 is made only in the brain, Dr. McGeer’s team demonstrated that the peptide is made in all organs of the body and is secreted in saliva from the submandibular gland. As a result, with as little as one teaspoon of saliva, it is possible to predict whether an individual is destined to develop Alzheimer’s disease. This gives them an opportunity to begin taking early preventive measures such as consuming non-prescription non-steroidal drugs (NSAIDs) such as ibuprofen.
“What we’ve learned through our research is that people who are at risk of developing Alzheimer’s exhibit the same elevated Abeta 42 levels as people who already have it; moreover, they exhibit those elevated levels throughout their lifetime so, theoretically, they could get tested anytime,” says Dr. McGeer. “Knowing that the prevalence of clinical Alzheimer’s Disease commences at age 65, we recommend that people get tested ten years before, at age 55, when the onset of Alzheimer’s would typically begin. If they exhibit elevated Abeta 42 levels then, that is the time to begin taking daily ibuprofen to ward off the disease.
“Unfortunately, most clinical trials to date have focused on patients whose cognitive deficits are already mild to severe, and when the therapeutic opportunities in this late stage of the disease are minimal. Consequently, every therapeutic trial has failed to arrest the disease’s progression. Our discovery is a game changer. We now have a simple test that can indicate if a person is fated to develop Alzheimer’s disease long before it begins to develop. Individuals can prevent that from happening through a simple solution that requires no prescription or visit to a doctor. This is a true breakthrough since it points in a direction where AD can eventually be eliminated.”
Aurin Biotech is a private, early stage Vancouver company which develops agents for the treatment of Alzheimer’s disease and other chronic degenerative diseases. The company was founded in 2012 to advance the discoveries made by the McGeer and Associates Laboratory at the University of British Columbia (UBC). For more information, visit http://www.aurinbiotech.com
Celebrating its 20th anniversary in 2018, the Journal of Alzheimer’s Disease is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer’s disease. The journal publishes research reports, reviews, short communications, book reviews, and letters-to-the-editor. Groundbreaking research that has appeared in the journal includes novel therapeutic targets, mechanisms of disease and clinical trial outcomes.
Contacts and sources:
Greg Descantes
IOS Press
Citation: Conquering Alzheimer’s Disease by Self Treatment
http://dx.doi.org/10.3233/JAD-179913 The Journal of Alzheimer’s Disease http://www.j-alz.com
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Whistler Blowers, Insiders
but die of Renal Failure
Or heart disease,Stroke !
FDA Strengthens Warning on NSAIDs and Heart Risk https://www.webmd.com/heart/news/20150710/fda-warning-nsaids-heart_risks#1
FDA strengthens warning that NSAIDs increase heart attack and stroke risk https://www.health.harvard.edu/blog/fda-strengthens-warning-that-nsaids-increase-heart-attack-and-stroke-risk-201507138138
Calls for ibuprofen sale restrictions after study finds cardiac arrest risk https://www.theguardian.com/society/2017/mar/15/ibuprofen-sale-restrictions-study-increased-cardiac-arrest-risk
I Would weigh up the BIG RISKS On The DOWNSIDE Re IBUPROFEN
This Is Jus US Gov FDA & Peer Reviewed Science Etc
………………………………………………………………………………………………………………………………………….
U.K NEWSPAPER
Study, published …. in The BMJ,
Taking ibuprofen to treat pain ‘for just…. ONE DAY ….. increases your risk …..of >>>> heart attack by …. 50 Per Cent’
The study, published in The BMJ (British Medical Journal), said their …..effect on heart attack risk ….. was almost immediate.
& Canadian experts found …. taking any regular …. dose of ibuprofen for between one to seven days raised chances by >>> 48 per cent.
https://www.thesun.co.uk/living/3520232/taking-ibuprofen-to-treat-pain-increases-your-risk-of-heart-attack-after-just-one-week/
…………………………………………………………………………………………………………………………………………………
FDA.GOV Strengthens Warning of Heart Attack and Stroke Risk for Non-Steroidal Anti-Inflammatory Drugs
Common OTC NSAIDs include …. ibuprofen (Motrin, Advil) and naproxen (Aleve).
The labels for both prescription NSAIDs and OTC NSAIDs already have information on …… heart attack …..and stroke risk.
FDA is strengthening ….an existing ….warning to indicate that nonsteroidal anti-inflammatory drugs (NSAIDs) can increase the chance ….of a heart attack or stroke, either of which >>> can lead to death
“There is …. no period ….of use…. shown to be…. without risk,” says Judy Racoosin, M.D., M.P.H., deputy director of FDA’s Division of Anesthesia, Analgesia, and Addiction Products.
https://www.fda.gov/ForConsumers/ConsumerUpdates/ucm453610.htm
…………………………………………………………………………………………………….
The agency (FDA) said it would …..ask drug manufacturers …..to change the labels to reflect new evidence that the drugs….
>>>> increased the risk of heart attack and stroke soon after …. patients first started ….. taking them,
and that while the risk was higher…. for people with heart disease, >>>> it surfaced ….even for people … who had ….. never had … heart problems.
https://www.nytimes.com/2015/07/14/science/experts-urge-sparing-use-of-nonaspirin-painkillers.html?_r=1
…………………………………………………………………………………………………………………………………..
THE NURSING TIMES
IBUPROFEN – Researchers warn it may – prolong symptoms.
Patients were also more likely …. to come back…. within a month
- with worsening ….. or new symptoms
If they were prescribed …. with ibuprofen ….. or ibuprofen with paracetamol, the study showed.
Around 50-70% of study participants prescribed ibuprofen or ibuprofen with paracetamol returned (with worsening ….. or new symptoms).
Professor Little admitted it was a “surprising result” and suggested ….the (Ibuprofen) treatment may contribute ….. to the progression (continuation) ….of the illness.
https://www.nursingtimes.net/clinical-archive/respiratory/cough-and-cold-patients-advised-not-to-take-ibuprofen/5065029.article
………………………………………………………………………………………………………………………………………………….
Quote .Gov (Medical Journal Published)
Ibuprofen and other widely used non-steroidal anti-inflammatory drugs inhibit antibody … production …. in human cells
The implications of this research are that the use of widely available NSAIDs after infection or vaccination may lower … host defenses.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2693360/
……………………………………………………………………………………………
U.S GOVERNMENT FDA (Food & DRUG Agency)
Ibuprofen tablets can cause serious gastrointestinal (GI) adverse events including inflammation, bleeding, ulceration, and perforation of the stomach, small intestine, or large intestine, which ….. can be >>> fatal.
Ibuprofen should be used in pregnancy only if …..the potential benefit justifies the potential
- risk … to the fetus.
https://www.drugs.com/pro/ibuprofen-800mg.html
……………………………………………………………………………………………………………………………………..
A recent Reuters’ article opened with the following stunning sentence:
“Long-term high-dose use of painkillers such as ibuprofen or diclofenac is ‘equally hazardous’ ….. in terms of >>heart attack risk as use of the drug
Vioxx, which was withdrawn….. due to …… its potential dangers, researchers said.”
Vioxx recall, as you may remember, was spurred by the nearly 30,000 …. excess cases of heart attacks and sudden cardiac deaths ….. caused by the drug between 1999-2003.
http://www.greenmedinfo.com/blog/ibuprofen-kills-more-pain-so-what-alternatives
……………………………………………………………………………………………………………………………
A new study reveals that a commonly consumed painkiller, wrongly considered “harmless” by millions, is probably causing.. thousands of deaths ……from cardiac arrest each year.
Diclofenac and ibuprofen, both commonly used drugs, were associated with significantly increased risk of cardiac arrest.
According to the Sudden Cardiac Arrest Foundation, sudden cardiac arrest (SCA) is a leading cause of death among adults over 40 in the United States and other countries, with about 326,200 people experiencing…. an out-of-hospital SCA…. each year in the US alone;
= 9 of 10 victims of SCA …. will die.
SCA – involves damage from…. the heart itself…. stopping. 3,376 of these were treated with an non-steroidal anti-inflammatory drug (NSAIDs) ….up to 30 days before the event. The most common NSAIDs used…… were ibuprofen (51%) and diclofenac (22%).
Our study adds …..to the evidence …. about the adverse cardiovascular effects ….. of NSAIDs and confirms that they should be taken seriously, and used only …..after consulting ….. a healthcare professional.”
http://www.greenmedinfo.com/blog/ibuprofen-can-stop-your-heart-31-increase-cardiac-arrest-risk
……………………………………………………………………………………………………………………………..
You choose how to “Roll The Dice” – I Will Give Ibuprofen A Miss
- At Least I Will Be …… MORE LIKELY to at least “LIVE LONG ENOUGH”…… that I might get to Alzheimers
YES – FOLLOW “THE MONEY”
Aurin Biotech is a private,……. early stage Vancouver company
- which develops agents for the treatment of Alzheimer’s disease and other chronic degenerative diseases.
The company was founded in 2012 to advance the discoveries made by the >>>>> McGeer and Associates Laboratory at the University of British Columbia (UBC).
It’s Hard For A Man To “UNDERSTAND SOMETHING” >>> When His Salary & Lifestyle “Depends On NOT Understanding it”