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What You Eat Likely Impacts Your Brain and Memory as You Age

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You may be familiar with the saying, “You are what you eat,” but did you know the food you eat could impact your memory?

Auriel Willette, assistant professor, and his team of researchers in Iowa State University’s Department of Food Science and Human Nutrition discovered a satiety hormone that, at higher levels, could decrease a person’s likelihood of developing Alzheimer’s disease. A paper outlining the results of their study recently was accepted for publication in Neurobiology of Aging.

Credit: Wikimedia Commons

Using data from the Alzheimer’s Disease Neuroimaging Initiative (ADNI), the researchers looked at the satiety hormone, Cholecystokinin (CCK), in 287 people. CCK is found in both the small intestines and the brain. In the small intestines, CCK allows for the absorption of fats and proteins. In the brain, CCK is located in the hippocampus, which is the memory-forming region of the brain, Willette said.

The researchers found for individuals who have higher CCK levels, their chance of having mild cognitive impairment, a precursor state to Alzheimer’s disease, or Alzheimer’s disease decreased by 65 percent.

“It will hopefully help to shed further light on how satiety hormones in the blood and brain affect brain function,” Willette said.

Auriel Willette, assistant professor of food science and human nutrition
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Why CCK?

Alexandra Plagman, lead author and graduate student in nutritional science, said they chose to focus on CCK because it is highly expressed in memory formation. The researchers wanted to see if there was any significance between levels of CCK and levels of memory and gray matter in the hippocampus and other important areas.

They also looked p-tau and tau proteins, which are thought to be toxic to the brain, to see how these might impact CCK and memory. They found that as tau levels increased, higher CCK was no longer related to less memory decline.

The researchers hope this study will encourage others to look into the nutritional aspect of diets, versus just looking at caloric intake. Plagman already is looking at how diet impacts an individual’s CCK levels through researching fasting glucose and ketone bodies.

“By looking at the nutritional aspect, we can tell if a certain diet could prevent Alzheimer’s disease or prevent progression of the disease,” Plagman said.

“The regulation of when and how much we eat can have some association with how good our memory is,” Willette added. “Bottom line: what we eat and what our body does with it affects our brain.”

Contacts and sources:
Auriel WilletteIowa State University

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    Total 3 comments
    • wheeties

      was going to read this article then forgot why so i didn’t- has anyone seen my car keys?

    • Hugh Fennell

      Great read, thanks for sharing!
      I love the statement “You are what you eat”. It is absolutely true. There are foods that can harm our health, but there also that can boost brain capabilities and improve memory. Some of them are fish, broccoli, nuts and others. More you can find here https://www.smartpillwiki.com/best-foods-for-boosting-brain-capability-what-you-should-eat-to-boost-your-memory/ .
      Best wishes, Hugh.

    • Hi NSA, kiss my artichoke

      Mitch? Is that you?
      I don’t know.
      So MANY coming and going and going and coming to BIN these days…
      Err… Wait… Squirrel!!!!!!!!!!!!!!!!!

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