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Marijuana’s Long Term Effects on the Brain Finally Revealed

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University of Texas just published their research into the long-term effects of marijuana

With a drug war against marijuana still raging in more countries than not, the question of how long-term marijuana use effects the human brain is a pivotal question in its legalization.  Although alcohol remains legal despite heaps of evidence to the dangers of long-term use, the fight to make marijuana available both with regard to its medical properties (especially in selectively killing cancer cells) and non-medical uses has frequently hinged on the various claims made about marijuana’s effects on the recreational user.

Luckily, the debate can finally move out from the realm of opinion into scientific evidence as researchers from the University of Texas just published their research into the long-term effects of marijuana use on the brain in PNAS (Proceedings of the National Academy of Sciences).

The researcher helped dispel the dying myth that marijuana use lowers IQ, and actually provides more evidence to marijuana’s potential role in fighting Alzheimer’s. The research revealed that earlier onset of regular marijuana use leads to greater structural and functional connectivity in the brain. The most significant increases in connectivity appear as an individual begins using marijuana, with results showing that the severity of use is directly correlated to greater connectivity.

Although these results will need to be confirmed with a larger sample (this was based on roughly 100 participants), the preliminary results do seem promising. More research will need to be done in order to see if these differences are caused by, or simply associated with, long term marijuana use. They also found reduced gray matter in the OFC (orbitofrontalcortex) in long-term users (which is a brain region associated with addiction). It is unclear whether this region is simply smaller in regular users (explaining their regular use) or if the use actually contributed to structural brain changes. These results will also need to be contrasted with other researcher showing that cannabinoids actually promote brain cell growth

One of the biggest question surrounding marijuana use, particularly by those who try to justify it being labeled a very dangerous and harmful drug, is the potential negative effects of long term use on the brain. Before tackling this question though, it should be pointed out the alcohol remains legal despite a long list of evidence validating that is is clearly dangerous relative to brain wellbeing.

Marijuana, on the other hand, has proven once again to be superior to alcohol, which researchers from the University of Texas demonstrated through research they published in the Proceedings of the National Academy of Sciences (PNAS) regarding the long term effects of marijuana on the brain.
Not only did the researchers debunk the myth that marijuana lowers IQ, and also presented evidence demonstrating that it can effectively fight Alzheimer’s, but they also reveal that regular marijuana use actually leads to greater connectivity in the brain!

Although these study results, which were convened on  will have to be corroborated in larger studies, 100 participants, the preliminary results are definitely positive and encouraging.

They also demonstrated another phenomenal finding that it helped reduce gray matter in the orbitofrontal cortex, or OFC, which is the brain region associated with addiction. Another remarkable result!
Although, again, this will have to be demostrated in bigger studies the results are obviously promising. Likewise, cannabinoids were also recently shown to promote brain cell growth (neurogensis) rather than destroy it.

In short, weed makes your brain stronger!

SOURCES:

http://pubs.niaaa.nih.gov/…

http://www.sciencedaily.com/…

http://www.washingtonpost.com/blogs/…

https://en.wikipedia.org/wiki/…

http://www.ncbi.nlm.nih.gov/…



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    Total 5 comments
    • Daryl 010

      And STILL most of the slaves cant have it! Lucky for those who dont want to feel better! Keep working & suffer on slaves! You’ll feel better in your next life, if your lucky. Have a nice cocktail, beer or 2 or 4! THAT will keep your mind off serving your masters in this world. Guarans. Cheer up, at least we can be obedient!

    • Daryl 0

      And STILL most of the slaves cant have it! Lucky for those who dont want to feel better! Keep working & suffer on slaves! You’ll feel better in your next life, if your lucky. Have a nice cocktail, beer or 2 or 4! THAT will keep your mind off serving your masters in this world. Guarans. Cheer up, at least we can be obedient!

      • Sean

        I would wonder why all of a sudden Pot is legal in many states.

        This article is not recent either – Date: November 10, 2014

        I think this guy Sadhguru had a pretty good take on Pot in general.

        https://youtu.be/-S2wAjLwNUs

        Published on Mar 18, 2011 [ FOR SOME ODD REASON YOUTUBE PUT AN AGE RESTRICTION ON THIS VIDEO ]

        This video deals exclusively with the documented negative health consequences of recreational cannabis use.

        I used data from over 140 papers in the process of preparing this video. I’ve done my best to document sources. Below are some key papers for reference.

        1. CANNABIS USE AND RISK OF LUNG CANCER: A CASE-CONTROL STUDY
        Eur Respir J. 2008 February; 31(2): 280–286.

        2. Possible role of marijuana smoking as a carcinogen in the development of lung cancer at a young age.
        J Psychoactive Drugs. 1994 Jul-Sep;26(3):285-8.

        3. Associations between duration of illicit drug use and health conditions: results from the 2005-2007 national surveys on drug use and health.
        Ann Epidemiol. 2010 Apr;20(4):289-97.

        4. Cannabis and road crashes: a survey of recent French studies.
        Ann Pharm Fr. 2006 May;64(3):192-6.

        5. Drugs in fatally injured young male drivers.
        Public Health Rep. 1985 Jan–Feb; 100(1): 19–25.

        6. Dose related risk of motor vehicle crashes after cannabis use.
        Drug Alcohol Depend. 2004 Feb 7;73(2):109-19.

        7. Developing limits for driving under cannabis.
        Addiction. 2007 Dec;102(12):1910-7.

        8. The effect of cannabis compared to alcohol on driving.
        Am J Addict. 2009; 18(3): 185–193.

        9. If cannabis caused schizophrenia–how many cannabis users may need to be prevented in order to prevent one case of schizophrenia? England and Wales calculations.
        Addiction. 2009 Nov;104(11):1856-61.

        10. Cannabis and suicide: longitudinal study.
        Br J Psychiatry. 2009 Dec;195(6):492-7.

        11. Cannabis use and the risk of developing a psychotic disorder.
        World Psychiatry. 2008;7(2):68-71.

        12. Delta-9-tetrahydrocannabinol effects in schizophrenia: implications for cognition, psychosis, and addiction.
        Biol Psychiatry. 2005 Mar 15;57(6):594-608.

        13. Adverse health effects of non-medical cannabis use.
        Lancet. 2009 Oct 17;374(9698):1383-91.

        14. General and oral health implications of cannabis use.
        Aust Dent J. 2005 Jun;50(2):70-4.

        15. Adverse health effects of non-medical cannabis use.
        Lancet. 2009 Oct 17;374(9698):1383-91.

        16. Adverse effects of cannabis on health: an update of the literature since 1996.
        Prog Neuropsychopharmacol Biol Psychiatry. 2004 Aug;28(5):849-63.

        17. Evaluating the drug use “gateway” theory using cross-national data: consistency and associations of the order of initiation of drug use among participants in the WHO World Mental Health Surveys.
        Drug Alcohol Depend. 2010 Apr 1;108(1-2):84-97.

        18. Does marijuana use serve as a gateway to cigarette use for high-risk African-American youth?
        Am J Drug Alcohol Abuse. 2008;34(6):782-91.

        https://youtu.be/nnNPm5cG85c

    • Anonymous

      The chemicals, responsible for causing inflammation, also appear to trigger new growth and repairs. So, someone, never to experience stress or pain, would be stunted. ref– hormesis.

      There are moral-masochist, gluttons for punishment, in this discussion. Also, unhinged hedonists. The voice of moderation will usually be hated, by both sides.

    • Arte Vespule

      No wonder I am so smart!!!

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