Evolution and the nature of aging
Wednesday, April 25, 2012 14:25
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We are eukaryotes, life forms
with chromosome pairs in cell nuclei having chromosome ends. Such
chromosomes have telemere ends which protect the genes and the gene regulating
DNA sections within the chromosomes. (Prokaryotes are simpler unicellular
life forms having no distinct nuclei. They instead have chromosome loops,
thus protectively having no fragile ends.)
with chromosome pairs in cell nuclei having chromosome ends. Such
chromosomes have telemere ends which protect the genes and the gene regulating
DNA sections within the chromosomes. (Prokaryotes are simpler unicellular
life forms having no distinct nuclei. They instead have chromosome loops,
thus protectively having no fragile ends.)
Aging to death after likely
sexually reproducing had long ago most usefully evolved in eukaryotes.
This had become advantageously highly important for producing needed
inheriting young. This had allowed more frequent descendants to thus
sometimes evolve quicker, to thus gradually remain a surviving species.
sexually reproducing had long ago most usefully evolved in eukaryotes.
This had become advantageously highly important for producing needed
inheriting young. This had allowed more frequent descendants to thus
sometimes evolve quicker, to thus gradually remain a surviving species.
Once developed beyond an embryo,
eukaryotes had in their replicating somatic (body) cells like fibroblasts, (but
not germ cells nor stem cells), a chromosome DNA
ends shortening characteristic. This restricted such cells to
ultimately be able to produce only a limited number of successive healthy cell
generations as adults aged. Yet, some aging was needed to occasionally
acquire rare random accidental cell chromosome errors in a few reproductive
cells, contributing gene alterations, a rare few being beneficial for advancing
most important slow gradual natural evolution.
Evolution had long ago developed this important nature, most
critical for having evolution continue vs. competing species, thanks to
produced new young generations. Such a helpful evolved nature forced limited
ages, then death for excessively aging adults, by having chromosome DNA ends
shortened each time somatic cells multiplied, due to not fully duplicating the
previous length and number of telomere ends there to protect cell chromosomes.
Thus the final generations of such somatic cells in adults aging too much
would end up also losing ends of good DNA from their repeatedly shortened
chromosomes, including ends of proper gene regulating DNA sections, such ends
required to be able to keep cells and an adult living healthy.
This became something like an
ever more destructive cell ticking time bomb. After too many ticks, the time bomb
could fatally ignite. More cells reproduced during increasing body age
would result in ever more shortened chromosome flaws, importantly causing death
if some adult in that species was living too long.
But cells becoming cancerous
often unfortunately switch on a gene that then expresses the chromosome-ends
protective enzyme telomerase, which is able to keep them producing
chromosome-ends protected bad new expanding cancerous cell generations,
(instead of future cancer cell generations loosing ever more from their
chromosome ends to most helpfully render them ultimately unable to forever keep
harmfully multiplying in forever expanding bad cancers in one’s body).
often unfortunately switch on a gene that then expresses the chromosome-ends
protective enzyme telomerase, which is able to keep them producing
chromosome-ends protected bad new expanding cancerous cell generations,
(instead of future cancer cell generations loosing ever more from their
chromosome ends to most helpfully render them ultimately unable to forever keep
harmfully multiplying in forever expanding bad cancers in one’s body).
Our required good most
importantly proper species reproductive cells had their chromosomes telomere
ends protected by telomerase vitally active in them, adding a proper fresh
number of protective telomere ends on new reproductive cell generations of
their chromosomes, for starting our needed new reproduced descendants, thus
resetting to zero in them such a cell ticking time bomb, to let them then live
long enough to mature and produce their own future new quite healthy fresh young, to thus keep the species
surviving and continuing, (while also slowly sometimes gradually most helpfully
competitively evolving).
This is a guest post. Questions?
Ask [email protected] .If interested in much more about advanced future folks living quite well in space,
ask for DOS compressed email attached FBW.Z
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