The Earliest Stages of Life Might Be Simpler Than We Thought
In the very earliest stages of life, mammalian cells multiply and form the embryo. New research from the University of Copenhagen suggests that this process might be much simpler than we thought. The development of the embryo can be cut down to the cell’s ability to count their neighboring cells.
Credit: University of Copenhagen
One of the things that make human beings and other mammals unique in the animal kingdom is our cells’ ability to remember how to make an embryo. Development is the process by which a single cell, a fertilized egg, makes a complex body with head, tail, arms and legs. Mammalian cells can begin this process without any apparent external or additional information to tell them which side is up and down.
“Cells are much smarter than we give them credit for. We have shown that they can build an embryo just by making four simple decisions. The most prominent of these is counting their neighbours. It almost sounds too simple to be true, but by counting their neighbours, the cells can determine whether they are placed on the outside or on the inside of the cell group. When they have made their decision, they adjust their properties, start to specialize and begin to form an embryo,” says Professor Josh Brickman from The Danish Stem Cell Center (DanStem).
The researchers used a computer simulation to make a cell-behaviour model. The idea was to find the minimal requirements for the cells to develop into an embryo, and the researchers cut it down to four rules or decisions for the cells to make based on their neighbours: adopt polarity, make lineage choices, alter its adhesion or die. They then tested the model in mice cells. The results showed that the model predicted the behaviour of the cells perfectly.
Development and evolution
The results also offer a further understanding of how evolution is even possible. In order for evolution to work, the genes that direct development have to change at a quite significant range. However, it is hard to conceive how the master control genes can change that drastically without messing the whole thing up.
“We have shown that by following the four simple rules, the cells will develop themselves. They only need a little bit of information from the genome, which allows evolution to play with the genes as much as it likes. Basically, it provides the robustness to ensure that development will always work, but then it gives evolution the room to play with the genome. This gives rise to the diversity of the mammalian species,” says PhD student from the Niels Bohr Institute Silas Boye Nissen.
The article ‘Four simple rules that are sufficient to generate the mammalian blastocyst’ is a product of StemPhys, a new multi-disciplinary initiative between SUND and the Niels Bohr Institute funded by the Danish National Research Foundation. The work is published in the journal PLoS Biology.
Contacts and sources:
Professor Josh Brickman
University of Copenhagen
Source: http://www.ineffableisland.com/2017/08/the-earliest-stages-of-life-might-be.html
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