Antioxidant Benefits of Sleep Discovered
Understanding sleep has become increasingly important in modern society, where chronic loss of sleep has become rampant and pervasive. As evidence mounts for a correlation between lack of sleep and negative health effects, the core function of sleep remains a mystery.
Image Credit: pbio.2005206
The researchers reasoned that if sleep is required for a core function of health, animals that sleep significantly less than usual should all share a defect in that core function. For this study, they used a diverse group of short-sleeping Drosophila (fruit fly) mutants. They found that these short-sleeping mutants do indeed share a common defect: they are all sensitive to acute oxidative stress.
Oxidative stress results from excess free radicals that can damage cells and lead to organ dysfunction. Toxic free radicals, or reactive oxygen species, build up in cells from normal metabolism and environmental damage. If the function of sleep is to defend against oxidative stress, then increasing sleep should increase resistance to oxidative stress. Hill and co-workers used both pharmacological and genetic methods to show that this is true.
Finally, the authors proposed, if sleep has antioxidant effects, then surely oxidative stress might regulate sleep itself. Consistent with this hypothesis, they found that reducing oxidative stress in the brain by overexpressing antioxidant genes also reduced the amount of sleep. Taken together, these results point to a bi-directional relationship between sleep and oxidative stress–that is, sleep functions to defend the body against oxidative stress and oxidative stress in turn helps to induce sleep.
This work is relevant to human health because sleep disorders are correlated with many diseases that are also associated with oxidative stress, such as Alzheimer’s, Parkinson’s, and Huntington’s diseases. Sleep loss could make individuals more sensitive to oxidative stress and subsequent disease; conversely, pathological disruption of the antioxidant response could also lead to loss of sleep and associated disease pathologies.
Contacts and sources:
PLOS Biology
PLOS
Source: http://www.ineffableisland.com/2018/07/antioxidant-benefits-of-sleep-discovered.html
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To get a truck driving job I had to buy a CPAP machine through the company just to get a job. After 10 months I quit and quit using the CPAP machine everyday , then I noticed black trash bag looking particals coming out of my nose while sleeping. Pieces would be on my ears, chest, bed, around 3 to 10 flakes a night. I don’t notice them after a month
So many speaking and writing about how bad sleeplessness is but actually nothing about how to solve that. So oxidative stress is causing insomnia – so what do you do about oxidative stress?????