Research Uncovers Potential Health Risks of Travel to Mars

For the study, human HSCs from healthy donors of typical astronaut age (30-55 years) were exposed to Mars mission-relevant doses of protons and iron ions – the same types of radiation that astronauts would be exposed to in deep space — at the NASA Space Radiation Laboratory at Brookhaven National Laboratory. Researchers at the Wake Forest Institute for Regenerative Medicine then performed laboratory and animal studies to define the impact of the exposure.

These exposure levels that simulated deep space radiation were found to dramatically affect the health and function of the HSCs. “Radiation exposure at these levels was highly deleterious to HSC function, reducing their ability to produce almost all types of blood cells, often by 60-80 percent,” said Porada. “This could translate into a severely weakened immune system and anemia during prolonged missions in deep space.”
Previous studies by other researchers had already demonstrated that exposure to high doses of earthly radiation, such as from X-rays, can have harmful (even life-threatening) effects on the body’s ability to make blood cells, and can significantly increase the likelihood of cancers, especially leukemias. However, the current study was the first to show a damaging effect of low, mission-relevant doses of space radiation.

The current study is significant because it shows that radiation affected cells at the stem cell level. It caused mutations in genes involved in the hematopoietic process, and it dramatically reduced the ability of HSCs to give rise to mature blood cells.

The next step was to assess how the cells would function in the body. Mice were transplanted with GCR-irradiated human HSCs, essentially “humanizing” the animals. The mice developed what appears to be T-cell acute lymphoblastic leukemia – the first demonstration that exposure to space radiation may increase the risk of leukemia in humans.

Mars Outpost: 1989 Concept

Credit:NASA/Mark Dowman

“Our results show radiation exposure could potentially increase the risk of leukemia in two ways,” said Porada. “We found that genetic damage to HSCs directly led to leukemia. Secondly, radiation also altered the ability of HSCs to generate T and B cells, types of white blood cells involved in fighting foreign ‘invaders’ like infections or tumor cells. This may reduce the ability of the astronaut’s immune system to eliminate malignant cells that arise as a result of radiation-induced mutations.”

Porada said the findings are particularly troubling given previous work showing that conditions of weightlessness/microgravity present during spaceflight can also cause marked alterations in astronaut’s immune function, even after short duration missions in low earth orbit, where they are largely protected from cosmic radiation. Taken together, the results indicate that the combined exposure to microgravity and SEP/GCR radiation that would occur during extended deep space missions, such as to Mars, could potentially exacerbate the risk of immune-dysfunction and cancer.

NASA’s Human Research Program is exploring not only the effects of radiation, but also conditions of microgravity, isolation and confinement, hostile and closed environments, and distance from earth. The ultimate goal of the research is to make space missions as safe as possible.

Co-authors are: Graça Almeida-Porada, M.D., Ph.D.; Christopher Rodman; Sunil George, Ph.D.; John Moon; Shay Soker, Ph.,D.; Timothy Pardee, M.D., Ph.D.; Michael Beaty, M.D.; Satria P. Sajuthi, Ph.D.; Carl D. Langefeld, Ph.D.; and Stephen J. Walker, Ph.D, Wake Forest Baptist; Peter Guida, Ph.D., Brookhaven National Laboratory; and Paul F. Wilson, Ph.D., Brookhaven National Laboratory and the Univ. of California Davis Comprehensive Cancer Center.

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