Altered animals: Creatures with bonus features (Animals that glow & other creepy alterations)
Gallery: Fluorescent felines meet pre-plucked chickens
UNLESS you live in Europe, your last meal probably contained genetically modified ingredients – 80 per cent of soya grown worldwide is now genetically engineered, for instance. Yet while modified plants are rapidly taking over the planet’s farms, the same cannot be said for GM animals. There’s the occasional flurry of reports about glowing rabbits or marmosets, but no one is yet eating beef from bioengineered bullocks.
The main reason is that the genetic engineering of animals – with the exception of mice – has been a slow, tedious process needing a lot of money and not a little luck. Behind the scenes, though, a quiet revolution has been taking place. Thanks to a set of new tricks and tools, modifying animals is becoming a lot easier and more precise. That is not only going to transform research, it could also transform the meat and eggs you eat and the milk you drink.
The first transgenic animals were produced by injecting DNA into eggs, implanting the eggs in animals and then waiting weeks or months to see if any offspring had incorporated the extra DNA. Often fewer than 1 in 100 had, making this a long, expensive process. “That’s just really inefficient,” says Scott Fahrenkrug, a geneticist at the University of Minnesota in St Paul.
In mice, geneticists found a way round this problem: producing cells with the desired modification first, before growing entire animals. The researchers alter the DNA in embryonic stem cells growing in a dish, then inject successfully modified cells into embryos. This yields chimeras with a mixture of cells that can be bred to produce mice in which all the cells are modified. It has become cheap and easy: there are now many millions of GM mice in labs worldwide, including extraordinary creations like the “supermouse” capable of running twice as far as normal, “brainbow” mice whose neurons light up in different colours and even mice that do not fear cats.
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