Earwax: A New Frontier Of Human Odor Information

Preti’s interest in earwax was piqued by the finding that a small change in a gene known as ABCC11 is related both to underarm odor production and also to whether a person has wet or dry earwax.

Individuals of East Asian (e.g., Chinese, Korean and Japanese) and Native American descent have a form of the ABCC11 gene that codes both for dry-type earwax and also for reduced underarm body odor relative to individuals of other ethnicities, who typically produce a wet-type ear wax and greater body odor.

To explore whether earwax has a characteristic odor, the researchers collected earwax from 16 healthy men: eight Caucasian and eight of East Asian descent. Each sample was placed into a vial, which was gently heated for 30 minutes to promote release of airborne molecules known as volatile organic compounds ( VOCs), many of which are odorous.

An absorbent device was then inserted through the vial’s cap to collect VOCs from the closed containers, and gas chromatography-mass spectrometry techniques used to analyze the chemical compounds.

The analysis revealed 12 VOCs were consistently present in the earwax of all the men. However, the amount of VOCs varied as a function of the subject’s ethnic background, with Caucasians having greater amounts of 11 of the 12 VOCs than East Asians.

“In essence, we could obtain information about a person’s ethnicity simply by looking in his ears. While the types of odorants were similar, the amounts were very different,” said study lead author Katharine Prokop-Prigge, a Monell chemist.

The researchers suspect that the fatty nature of earwax makes it a likely repository for lipid-soluble odorants produced by certain diseases and the environment.

Prokop-Prigge points out that at least two odor-producing metabolic diseases (maple syrup urine disease and alkaptonuria) can be identified in earwax before they can be diagnosed using traditional techniques such as blood and urine analysis.

“Odors in earwax may be able to tell us what a person has eaten and where they have been,” said Preti. “Earwax is a neglected body secretion whose potential as an information source has yet to be explored.”

Future studies will examine these possibilities.

Contacts and sources:
Leslie Stein
Monell Chemical Senses Center