Cell Transplant Restores Vision in Rats - A Step Toward Restoring Age Related Vision Loss
Degeneration of the retina as a result of age or progressive eye disease damages the light-detecting cells necessary for accurate vision. Current treatments can only help protect existing cells from further damage and are ineffective during late stages of disease once these cells are gone. Retinal sheet transplants have been demonstrated in prior animal and human studies, but their ability to restore complex vision has not yet been assessed.Figure 3A) PKCα is a marker of rod bipolar cells and labels both the host (hPAP-, red) and donor (hPAP+, green) tissue. Donor bipolar cells (yellow) surround photoreceptor rosettes (white asterisks) and interact with photoreceptor terminals to form a putative outer plexiform layer.
Credit: Foik et al., JNeurosci (2018)
JNeurosci, the Society for Neuroscience’s first journal, was launched in 1981 as a means to communicate the findings of the highest quality neuroscience research to the growing field. Today, the journal remains committed to publishing cutting-edge neuroscience that will have an immediate and lasting scientific impact, while responding to authors’ changing publishing needs, representing breadth of the field and diversity in authorship.
Contacts and sources:
David BarnstoneThe Society for Neuroscience
Citation: Detailed visual cortical responses generated by retinal sheet transplants in rats with severe retinal degeneration
DOI: https://doi.org/10.1523/JNEUROSCI.1279-18.2018
Corresponding author: David Lyon (University of California, Irvine, USA .
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