Read the Beforeitsnews.com story here. Advertise at Before It's News here.

By Alton Parrish (Reporter)
Contributor profile | More stories

Story Views
Now:
Last hour:
Last 24 hours:
Total:

Why Do Hydra End Up With Just A Single Head?

Monday, January 21, 2019 10:17

% of readers think this story is Fact. Add your two cents.

The ability of Hydra to regenerate or maintain a single head results from a subtle balance between activating and inhibiting activities. The latter has just been identified by a University of Geneva (UNIGE) group.

The freshwater Hydra is able to regenerate any part of its body to rebuild an entire individual. The small polyp has a development organizer center located at the head level, and another located in the foot. The head organizer performs two opposite activities, one activating, which causes the head to differentiate, and the other inhibiting, which prevents the formation of supernumerary heads.

Researchers at the University of Geneva (UNIGE), Switzerland, have discovered the identity of the inhibitor, a protein called Sp5, and deciphered the dialogue between these two antagonistic activities, which helps maintain a single-headed adult body and organize an appropriate regenerative response. Published in the journal Nature Communications, their study points out that this mechanism has been conserved throughout evolution, both in Hydra and in humans. Sp5 could therefore be an excellent candidate to be tested as an inhibitor of human tumors in which the activator pathway is the motor of proliferation.

Often considered immortal, the freshwater Hydra has a prodigious regenerative power, discovered by the Geneva naturalist Abraham Trembley nearly 300 years ago. Any fragment of the body with a few thousands cells can regenerate the entire animal, which measures about one centimeter. “Regeneration of the head relies on the transformation of the stump into a tissue called the head organizing centre, which has developmental properties and, like an architect, directs the construction of the future head”, explains Brigitte Galliot, professor at the Department of Genetics and Evolution of the UNIGE Faculty of Science.

How the dialogue between Yin and Yang takes shape

The head organizer carries out two opposite activities, one activating and the other inhibiting. The first induces the differentiation of stem cells into specialized head cells. The activator is a growth factor called Wnt3, whose action allows the initiation of a three-dimensional cell differentiation program that enables the construction of the head. Thus, in the absence of Wnt3, the head regeneration program cannot proceed. The inhibitory activity, produced under the control of the activator activity, prevents the formation of supernumerary heads. “These two antagonistic activities establish a dialogue between them, but we knew neither the identity of the inhibitor nor the nature of this dialogue”, says the biologist.

A Hydra that produces too little Sp5 spontaneously develops multiple heads.

Credit: © Brigitte Galliot, UNIGE

Using the results of a study conducted by a German team on the planarian flatworm, the biologists developed a gene screening strategy to identify this inhibitor. “We started from 124 candidates who met specific criteria to single out a unique winner, who met all of them. It is a gene that codes for a protein called Sp5″, says Matthias Vogg, researcher at the Department of Genetics and Evolution of the UNIGE Faculty of Science and first author of the study. The scientists then demonstrated that Sp5 binds to the regulatory region of the gene that codes for Wnt3, blocks its expression and thus the formation of the head.

The seven heads of the freshwater Hydra

How does the dialogue between the activator pathway and the inhibitor work? “We have quantified the expression of the genes encoding Wnt3 and Sp5 in different parts of the body of intact or amputated Hydra, and discovered that a regulatory loop between the two activities is established according to the location and quantity of each gene expressed”, notes Brigitte Galliot. Thus, in intact animals, the growth factor Wnt3 will be mainly present at the tip of the head, while Sp5 will be primarily active in the surrounding area, to prevent the appearance of other heads.

When researchers block the expression of Sp5, Hydra polyps, intact or regenerating, develop multiple heads, all perfectly functional, their tentacles apprehending the food to lead it to the mouth. “We also replicated these results from Hydra polyps whose cells had been completely dissociated from each other, then reaggregated and left in culture: multi-headed Hydra re-formed completely in four to five days”, explains Matthias Vogg.

In humans, the cell signaling pathway activated by Wnt3 is mainly active during embryonic development, as well as in different types of tumors in adults. If the inhibitory effect of Sp5 is confirmed in our species, this protein could be a candidate treatment targeting cancer cells that use the Wnt3 pathway to proliferate.

Contacts and sources:
Brigitte Galliot
University of Geneva

Citation: An evolutionarily-conserved Wnt3/β-catenin/Sp5 feedback loop restricts head organizer activity in Hydra Matthias C. Vogg, Leonardo Beccari, Laura Iglesias Ollé, Christine Rampon, Sophie Vriz, Chrystelle Perruchoud, Yvan Wenger & Brigitte Galliot Nature Communications volume 10, Article number: 312 (2019) http://dx.doi.org/10.1038/s41467-018-08242-2

Source:

Before It’s News® is a community of individuals who report on what’s going on around them, from all around the world.

Anyone can join.
Anyone can contribute.
Anyone can become informed about their world.

"United We Stand" Click Here To Create Your Personal Citizen Journalist Account Today, Be Sure To Invite Your Friends.

Please Help Support BeforeitsNews by trying our Natural Health Products below!

Order by Phone at 888-809-8385 or online at https://mitocopper.com M - F 9am to 5pm EST

Order by Phone at 866-388-7003 or online at https://www.herbanomic.com M - F 9am to 5pm EST

Order by Phone at 866-388-7003 or online at https://www.herbanomics.com M - F 9am to 5pm EST

Humic & Fulvic Trace Minerals Complex - Nature's most important supplement! Vivid Dreams again!

HNEX HydroNano EXtracellular Water - Improve immune system health and reduce inflammation.

Ultimate Clinical Potency Curcumin - Natural pain relief, reduce inflammation and so much more.

MitoCopper - Bioavailable Copper destroys pathogens and gives you more energy. (See Blood Video)

Oxy Powder - Natural Colon Cleanser! Cleans out toxic buildup with oxygen!

Nascent Iodine - Promotes detoxification, mental focus and thyroid health.

Smart Meter Cover - Reduces Smart Meter radiation by 96%! (See Video).

Comments

Online:
Visits:	1,603,238,712
Stories:	8,149,407