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A Remedy Which Processes Anti-inflammatory Activity

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By Kyle J. Norton

Scientists may have a herbal medicine which may reduce risk and treat diseases associated with inflammation, some studies suggested.

Inflammation is a natural defense that protects our body against the invasion of foreign stimuli, including damaged cells, irritants, pathogens.

In the body tissue damage caused by physical impact or other sources, macrophages, the immune first ile of defense, stimulating the production of proinflammatory cytokines to the site with an aim to protect our body by destroying possible bacteria or virus invasion.

However, in most cases, a prolonged period of overproduction of inflammatory cytokines can cause damage and death of the healthy cells leading to tissue damage and the formation of abnormal scars after healing. The liver scar is one of the examples.

Some cytokines process such as interleukin-6 (IL-6) a duo function of pro and anti-inflammatory activity. Under normal condition, the protein produces anti-inflammatory cytokines against substances that cause inflammation such as oxidative stress, however, in sensing of the bodily injury and damage, these proteins switch to produce proinflammatory cytokines.


Chronic inflammation is inflammation that lasts more than 3 months, occurred when the immune systematic response cannot destroy all pathogens in the acute phase of infection.


Chronic inflammation also can be caused by an autoimmune disorder in which the immune white blood cells mistakenly attack the body localized tissue, such as cancers and rheumatoid arthritis.


Symptoms associated with acute inflammation are depending on the location of the inflammation. including pain, swelling, redness, and heat.


Arnica is a herbaceous species, genus perennial, belonging to the family Asteraceae, native to Europe and Asia.

The herb has been used in herbal medicine for centuries to treat strains, sprains, and bruises.
Inflammation is a condition of Immune system self-protection to remove harmful … from our body.

The ingredients
Beside containing helenalin as it main ingredient used as an anti-inflammatory agent in herbal medicine, it also contains 11,13- dihydrohelenaline, chamissonolid, Sesquiterpene lactone, lignans of the furofuran, dibenzylbutyrolactone, dibenzylbutyrolactol types, pinoresinol, epipinoresinol, phillygenin, matairesinol, nortrachelogenin, and nortracheloside, six dibenzylbutyrolactol derivative, etc.

In the study to reaffirm the traditional claim that herbal Arnica montana, in topical formulations process anti-inflammatory activity, researchers at the Pontificia Universidade Católica de Brasília, launched an investigation determine whether Arnica montana 6cH decreases acute and chronic inflammation in animal models.


In the acute, model, carrageenin-induced rat paw edema, the group treated with Arnica montana 6cH showed 30% inflammatory inhibition compared to control.

However, Treatment with Arnica 6cH, 30 min prior to carrageenin, did not produce any inhibition of the inflammatory process.

In the chronic model, Nystatin-induced edema, Arnica montana 6cH treatment after 3 days of injection of Nystatin, exerts a significantly reduced inflammation 6 h after the last dose of the inflammatory agent was applied compared to insignificant result when treatment was given 6 h after Nystatin treatment.

In a model based on the histamine-induced increase of vascular permeability, pretreatment with Arnica montana 6cH blocked the action of histamine in increasing vascular permeability.


These results suggested that Arnica montana 6cH induce the anti-inflammatory effects in a dose and time-dependent manner.


Additionally, in the study to compare two types of gels and microemulsions used to dissolve, release, and induce the permeation of helenalin, a flavonoid responsible for the anti-inflammatory activity of arnica Montana extract, and aloin, an anthrone-C-glucosyls with antibacterial activity present in aloe vera extract, researchers found that microemulsion can be a good vehicle to increase the permeation of helenalin, while the gel formulation, containing Sepigel 305, proved able to reduce the release and permeation of aloin, with a consequent activity limited to the surface of application, without any permeation. in a modified Franz cell and a porcine skin membrane.


These results suggested Arnica montana gel may be a good choice in reduced skin inflammation if it is used combined with a microemulsion, which processes the function in increasing the permeation of helenalin.

Taken all together, Herbal Arnica may be considered a functional food for the prevention and an adjunct therapy combined with primary medicine for the treatment of acute and chronic inflammatory diseases.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it’s news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada – Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma and Bioscience, ISSN 0975-6299.

(1) Contact allergy to Compositae plants in patients with atopic dermatitis. [Article in English, Serbian]” by Jovanović M, Poljacki M, Duran V, Vujanović L, Sente R, Stojanović S.,(PubMed)
(2) Anti-inflammatory activity of Arnica montana 6cH: preclinical study in animals by Macêdo SB, Ferreira LR, Perazzo FF, Carvalho JC. (PubMed)
(3) Effect of vehicles on topical application of aloe vera and arnica Montana components by Bergamante V, Ceschel GC, Marazzita S, Ronchi C, Fini A.(PubMed)

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