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How to Protect the Neurons Integrity and Viability

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By Kyle J. Norton

Scientists may have found a pungent spice which processes a potential for the treatment of neurological diseases, according to studies.

Neurological diseases are medical conditions associated with the brain, spinal core, and the nerves of the central nervous system.

Depending on the location of the damage, people with the neurological disease may experience symptoms that affect the moving, speaking, swallowing, breathing, or learning.

There are over 600 types of neurological diseases. However, according to the World Health Organization, migraines and Alzheimer’s disease are the 2 most common types of neurological diseases, affecting 326 million and 24 millions worldwide population respectively.

Most common risk factors that cause the onset of the medical condition include genetic preposition, environmental influences, and physical injuries.

Some researchers suggested that an unhealthy lifestyle are the major causes of neurological diseases in North American.

Dr. Null G in examing the lifestyle choice and chronic diseases wrote, “an intervention of diet and lifestyle, including a vegan diet, fruit, and vegetable juices, nutritional supplements, regular exercise, and distressing techniques, would affect 27 subjects with anxiety, depression, poor memory, dementia, Alzheimer’s disease, Parkinson’s disease, history of stroke, or multiple sclerosis. Several subjects had overlapping conditions”.


Therefore, it is clear to all people that following a healthy diet with a high amount of fruits, and vegetables and moderated exercise are the best to reduce the risk of the neurological disorder.

Ginger (Zingiber officinale) or ginger root, the second superfood used for thousands of years by mankind, is the genus Zingiber, belonging to the family Zingiberaceae, native to Tamil.

The root has been used in traditional and Chinese medicine for the treatment dyspepsia, gastroparesis, constipation, edema, difficult urination, colic, etc.

Researchers on finding a natural compound with less cost for the treatment of neurological diseases examined the neuroprotective and memory enhancing effect of [6]-gingerol (GIN), a pungent ingredient of ginger, in an animal model of amnesia.


In cognitive dysfunction C57BL/6 mice induced by the injection of scopolamine (SCO, 1 mg/kg, i.p.), tested mice demonstrated a behavior changes and memory impairments, such as decreased alteration (%). 


According to the assay observed after infection of SCO, tested mice also displayed an increased mean escape latency in water maze test, diminished step-through latency in passive avoidance test, and shortened the freezing time in fear condition test,


Application of 6-gingerol at 10 or 25 mg/kg/day not only exerted a clinical statistic in restoring all the changes induced by SCO but also improved the function of neuroactivity.


The results were attributed to the 6-gingerol neuroprotective mechanism in focusing on the brain-derived neurotrophic factor (BDNF), involved the canonical nerve growth factor.


Dr. the lead scientist said, “GIN may have preventive and/or therapeutic potentials in the management of memory deficit and cognitive impairment in mice with amnesia”.


In order to reveal more information about ginger neuroprotective effects, researchers investigated the role of 6-gingerol on inhibiting amyloid β protein-induced apoptosis in PC12 cells.


Ginger reversed the behavioral dysfunction and prevented Alzheimer’s disease (AD)-like symptoms induced by the amyloid-β protein (Aβ) in a rat model.


Pre-treatment with 6-gingerol significantly increased cell viability and reduced cell apoptosis in Aβ1–42-treated cells.


Furthermore, pretreatment of 6-gingerol not only markedly reduced the level of intracellular reactive oxygen species (ROS) and malondialdehyde (MDA), but also inhibited the production of proinflammatory cytokine and leakage of enzymes involved turning sugar into energy and high low-density lipoprotein LDH.


Moreover, 6-gingerol also improved the production of antioxidant enzymes produced by the host such as superoxide dismutase (SOD) activity compared with the Aβ1–42 treatment group.


These findings strongly suggested that 6-gingerol exhibited protective effects on neuron apoptosis induced by Aβ1–42 in cultured PC12 cells by reducing oxidative stress and inflammatory responses and mutated gene expression involved neuronal cell development and enhanced protein functions on the association of cellular process.


Taken altogether, ginger processed abundantly 6-gingerol may be considered a neuroprotective functional remedy, pending to the confirmation of large sample size and multicenter human study.


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Author Biography
Kyle J. Norton (Scholar, Master of Nutrition, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published online, including worldwide health, ezine articles, article base, health blogs, self-growth, best before it’s news, the karate GB daily, etc.,.
Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Named 50 of the best health Tweeters Canada – Huffington Post
Nominated for shorty award over last 4 years
Some articles have been used as references in medical research, such as international journal Pharma ISSN 0975-6299.

(1) Neuroprotective Effect and Molecular Mechanism of [6]-Gingerol against Scopolamine-Induced Amnesia in C57BL/6 Mice byChang-Yul Kim,1 Yongtaek Seo,2 Chan Lee,2 Gyu Hwan Park,3 and Jung-HeeJang. (Hindawi)
(2) The Role of 6-Gingerol on Inhibiting Amyloid β Protein-Induced Apoptosis in PC12 Cells by Gao-feng Zeng,1,* Shao-hui Zong,2,* Zhi-yong Zhang,1 Song-wen Fu,1 Ke-ke Li,3 Ye Fang,3Li Lu,1 and De-qiang Xiao. (PMC)
(3) Nutrition and Lifestyle Intervention on Mood and Neurological Disorders by Null G1, Pennesi L2, Feldman M. (PubMed)

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