Read the Beforeitsnews.com story here. Advertise at Before It's News here.
Profile image
Story Views
Now:
Last hour:
Last 24 hours:
Total:

What is Padeliporfin? An Overview

% of readers think this story is Fact. Add your two cents.


In the realm of cancer treatment, innovative therapies are continually being developed to offer patients more effective and less invasive options. One such groundbreaking therapeutic agent is Padeliporfin, primarily used in vascular-targeted photodynamic therapy (VTP). This article delves into the specifics of Padeliporfin, its applications, and the latest research findings.

For those interested in exploring more about the cutting-edge technologies in cancer treatment, visit ImPact Biotech to learn about their pioneering work in developing precise and safe therapeutic solutions.

Understanding Padeliporfin

Padeliporfin is a vascular-acting photosensitizer used in the treatment of low-risk prostate cancer and upper tract urothelial carcinoma (UTUC). It works by leveraging the principles of photodynamic therapy, where a light-sensitive medication is activated by a specific wavelength of light to destroy cancer cells.

Mechanism of Action

The mechanism of Padeliporfin involves its intravenous administration followed by the application of a 753 nm wavelength laser light. This light activation triggers a photochemical reaction that generates oxygen radicals, leading to local hypoxia and the destruction of the target tissue. The process is confined to the vascular system, minimizing damage to surrounding healthy tissues.

Applications in Cancer Treatment

Prostate Cancer

Padeliporfin has been approved for the treatment of low-risk prostate cancer in adults. It offers a focal treatment approach, aiming to destroy only the cancerous lesions without affecting the entire prostate gland. This method is particularly beneficial for patients with unilateral, low-risk adenocarcinoma of the prostate.

Upper Tract Urothelial Carcinoma (UTUC)

The ENLIGHTED trial, a phase 3 study, is currently investigating the efficacy and safety of Padeliporfin VTP in treating low-grade UTUC. Preliminary results have shown promising evidence of safety and efficacy, with a significant number of patients achieving complete or partial responses.

Clinical Trials and Research Findings

The ENLIGHTED trial has reached a significant milestone with over 50% patient enrollment. The study aims to assess the efficacy and durability of Padeliporfin VTP in treating low-grade UTUC. Interim results presented at the 2024 American Society of Clinical Oncology (ASCO) Annual Meeting highlighted the therapy’s potential as a best-in-class treatment for this condition.

Safety and Efficacy

Preliminary data from the ENLIGHTED trial indicate that Padeliporfin VTP is safe and effective. The majority of adverse events were grade 1-2 in severity, with no instances of grade 4-5 adverse events. These findings suggest that Padeliporfin VTP could offer a valuable treatment option for patients with low-grade UTUC.

Conclusion

Padeliporfin represents a significant advancement in the field of vascular-targeted photodynamic therapy. Its applications in treating low-risk prostate cancer and upper tract urothelial carcinoma offer new hope for patients seeking less invasive and more targeted treatment options. As research continues to unfold, the potential of Padeliporfin VTP as a best-in-class therapy becomes increasingly evident.

Latest 2024 News

  • ENLIGHTED Trial Progress: The phase 3 ENLIGHTED trial has reached over 50% patient enrollment, marking a crucial milestone in the development of Padeliporfin VTP for low-grade UTUC.

  • Preliminary Results: Interim results from the ENLIGHTED trial presented at the 2024 ASCO Annual Meeting have shown promising evidence of safety and efficacy.

  • Future Prospects: The study is expected to provide the basis for approval of Padeliporfin VTP as a new therapy for low-grade UTUC, with complete enrollment anticipated by the first quarter of 2025.



Before It’s News® is a community of individuals who report on what’s going on around them, from all around the world.

Anyone can join.
Anyone can contribute.
Anyone can become informed about their world.

"United We Stand" Click Here To Create Your Personal Citizen Journalist Account Today, Be Sure To Invite Your Friends.

Before It’s News® is a community of individuals who report on what’s going on around them, from all around the world. Anyone can join. Anyone can contribute. Anyone can become informed about their world. "United We Stand" Click Here To Create Your Personal Citizen Journalist Account Today, Be Sure To Invite Your Friends.


LION'S MANE PRODUCT


Try Our Lion’s Mane WHOLE MIND Nootropic Blend 60 Capsules


Mushrooms are having a moment. One fabulous fungus in particular, lion’s mane, may help improve memory, depression and anxiety symptoms. They are also an excellent source of nutrients that show promise as a therapy for dementia, and other neurodegenerative diseases. If you’re living with anxiety or depression, you may be curious about all the therapy options out there — including the natural ones.Our Lion’s Mane WHOLE MIND Nootropic Blend has been formulated to utilize the potency of Lion’s mane but also include the benefits of four other Highly Beneficial Mushrooms. Synergistically, they work together to Build your health through improving cognitive function and immunity regardless of your age. Our Nootropic not only improves your Cognitive Function and Activates your Immune System, but it benefits growth of Essential Gut Flora, further enhancing your Vitality.



Our Formula includes: Lion’s Mane Mushrooms which Increase Brain Power through nerve growth, lessen anxiety, reduce depression, and improve concentration. Its an excellent adaptogen, promotes sleep and improves immunity. Shiitake Mushrooms which Fight cancer cells and infectious disease, boost the immune system, promotes brain function, and serves as a source of B vitamins. Maitake Mushrooms which regulate blood sugar levels of diabetics, reduce hypertension and boosts the immune system. Reishi Mushrooms which Fight inflammation, liver disease, fatigue, tumor growth and cancer. They Improve skin disorders and soothes digestive problems, stomach ulcers and leaky gut syndrome. Chaga Mushrooms which have anti-aging effects, boost immune function, improve stamina and athletic performance, even act as a natural aphrodisiac, fighting diabetes and improving liver function. Try Our Lion’s Mane WHOLE MIND Nootropic Blend 60 Capsules Today. Be 100% Satisfied or Receive a Full Money Back Guarantee. Order Yours Today by Following This Link.


Report abuse

    Comments

    Your Comments
    Question   Razz  Sad   Evil  Exclaim  Smile  Redface  Biggrin  Surprised  Eek   Confused   Cool  LOL   Mad   Twisted  Rolleyes   Wink  Idea  Arrow  Neutral  Cry   Mr. Green

    MOST RECENT
    Load more ...

    SignUp

    Login

    Newsletter

    Email this story
    Email this story

    If you really want to ban this commenter, please write down the reason:

    If you really want to disable all recommended stories, click on OK button. After that, you will be redirect to your options page.