Read the story here. Advertise at Before It's News here.
Profile image
By FalkenBlog (Reporter)
Contributor profile | More stories
Story Views
Last hour:
Last 24 hours:

Cumulative vs. Simultaneous Mutations

% of readers think this story is Fact. Add your two cents.

 Intelligent design is fascinating because when biologists debate probabilities they often disagree by orders of magnitude. For example, Doug Axe looked at a Beta-Lactamase enzyme and estimated that the ratio of amino acid permutations that would fold correctly and break down ampicillin is one in 10^77. In contrast, evolutionists point to research that generates much larger likelihoods. Telomere discoverer and Nobelist Jack Szostak and Anthony Keefe estimated that the likelihood an 80-amino long protein can bind to inactivated ATP to be on the order of one in 10^12. Most estimates are around 1 in 10^50, but some are as low as one in a thousand.1

There are not many debates where scientists disagree by 77 orders of magnitude. While these researchers were looking at different proteins doing different things,2 they all thought their research was relevant to an essential question in evolutionary models: how smooth is the fitness landscape? To create new genes that created the original topoisomerase, or one of the 700 unique genes in both chimps and humans, it had to go from something—randomness, an existing or copied gene—to something new that aids fitness. Richard Dawkins portrays this as walking up a smooth hill behind what looks like an impenetrable cliff (Climbing Mount Improbable). This could be true, but not all peaks have smooth trails.  For example, assume an organism is at the blue dot in the graph above, where the x-axis represents a one-dimensional fitness landscape while the y-axis represents fitness (the fitness landscape was popularized by Sewall Wright in the 1930s).

It may be that many of the amino acids do not affect the functionality of the target protein. For example, one could argue that two specific mutations are needed, but only 212 of the other amino acids are necessary for functionality. In this case, we just change the number of total amino acids from the actual 424 to a ‘functional’ 212, as the others are irrelevant.

The mathematical intuition for this result is the following. The number of paths to the top row increases by a factor of 4 as one moves through time. In the chloroquine example, the top nodes represent all the combinations with two more up movements than down movements: up-up, up-down-up-up, etc. The probability of these successful paths declines by a factor of 0.001 because each path requires the extra p(u); a downward move implies an additional implausible upward move to get back to its earlier closeness to the target. The net probability–the number of paths times the probability, 4 × 0.001—therefore decreases by orders of magnitude at each step. Adding numbers that decline by an order of magnitude or more leaves the first digit unaffected, as when you add the numbers 0.01+0.0001+0.000001; the first term, 0.01, approximates the sum. In this way, the probability of a direct path number approximates the cumulative probability.

If we consider that mutations are like Poisson probabilities, happening randomly through time, the likelihood of two sequential specific mutations is equivalent to the probability of two simultaneous specific mutations. The direct sequence of mutations is precisely like the probability of a simultaneous mutation.

In the infinite limit, the odds of reaching the target are 1.0 regardless of how close one is to a target. The standard way of modeling probabilities ignores the pathways and looks at limits, obscuring this result.

While many paths lead to the target, as a practical matter, they are irrelevant. One can imagine all sorts of intermediate configurations of amino acids that are useful for something else, but that is not science unless one has a reasonable model or an empirical estimate of the ratio of these viable configurations to those possible. We all know that to turn a bicycle into a motorcycle you need several parts to work together. One can imagine each part being added without customers noticing, but one can also imagine a point where the thing does not work at all. To change an ion channel from one that lets only sodium across a membrane to one that allows only potassium, it too needs many specific mutations before it would work at either task. It could be there are many intermediate configurations that do something entirely different, but without any actual data, it takes a lot of faith to imagine these unseen functional intermediates are all buried in our past.

This process helps understand why looking at evolution in real-time on fruit flies, and E. coli shows nothing that would extrapolate to novel functionality. Instead, the more common involves loss of function. For example, losing melanin is advantageous for humans in northern latitudes because it allows humans to get more vitamin D. At the same time, the risk of skin cancer is lower with less sunlight, so the benefit of melanin is less. The sort of evolution we see all over within families like cats, dogs, and bears, however, does not explain how we got cats, dogs, and bears from a common ancestor.


Reidhaar-Olson and Sauer 1990 mutated the lambda-repressor in E. coli and found that only one in 10^63 sequences yield a functional repressor fold. Yockey 1977 calculated that the likelihood of generating a functional cytochrome c sequence is one in 10^65.


Axe checked how many amino sequences would have stable functional folds and maintain beta-lactamase enzyme activity. Szostak looked for proteins that bind to ATP, the largest family of all proteins. Most ligands bind to a single protein fold (83%), while the ATP binding binds to 35 different protein folds


The ignorance and indifference to probabilities among evolutionists are astounding. For a long time, many would just mention hundreds of millions of years and assume anything could happen. Most famously, in the Huxley-Wilberforce debate a mere year after Darwin published Origin of Species, Huxley suggested that a bunch of monkeys could produce the 23rd Psalm given enough time. The implication is that virtually anything is possible given enough time. The probability of typing Hamlet alone is around 10^184000, excluding punctuation. 500 million years would not give us the 23rd Psalm even if every bacteria were a monkey typing every second since the beginning of the universe.

This ignorance was highlighted when a researcher suggested that completely random mutations created a new protein in bacteria that degrades nylon. This assertion came from a misunderstanding popularized by professor of biology William Thwaites in 1985, who claimed that the enzymatic activity arose from a frameshift mutation within the bacteria that created an entirely novel sequence of amino acids. Such a mutation would shift every codon over one, creating an entirely new set of amino acids, like how changing one character affects a SHA-256 hash output.

It turned out the bacteria could already digest nylon, but the substitution of just two amino acids gave it a 153-fold increase in activity by widening a linkage cleft. While neat, that’s nothing like creating, say, topoisomerase or a ribosome. What’s interesting to me is that biologists could imagine that a random sequence of 392 amino acids would be functional. Clearly, professional biologists have a very different intuition on the probability of creating a new functional protein.


Before It’s News® is a community of individuals who report on what’s going on around them, from all around the world.

Anyone can join.
Anyone can contribute.
Anyone can become informed about their world.

"United We Stand" Click Here To Create Your Personal Citizen Journalist Account Today, Be Sure To Invite Your Friends.

Humic & Fulvic Liquid Trace Mineral Complex

HerbAnomic’s Humic and Fulvic Liquid Trace Mineral Complex is a revolutionary New Humic and Fulvic Acid Complex designed to support your body at the cellular level. Our product has been thoroughly tested by an ISO/IEC Certified Lab for toxins and Heavy metals as well as for trace mineral content. We KNOW we have NO lead, arsenic, mercury, aluminum etc. in our Formula. This Humic & Fulvic Liquid Trace Mineral complex has high trace levels of naturally occurring Humic and Fulvic Acids as well as high trace levels of Zinc, Iron, Magnesium, Molybdenum, Potassium and more. There is a wide range of up to 70 trace minerals which occur naturally in our Complex at varying levels. We Choose to list the 8 substances which occur in higher trace levels on our supplement panel. We don’t claim a high number of minerals as other Humic and Fulvic Supplements do and leave you to guess which elements you’ll be getting. Order Your Humic Fulvic for Your Family by Clicking on this Link , or the Banner Below.

Our Formula is an exceptional value compared to other Humic Fulvic Minerals because...


It Always Tests at 9.5+ pH

Preservative and Chemical Free

Allergen Free

Comes From a Pure, Unpolluted, Organic Source

Is an Excellent Source for Trace Minerals

Is From Whole, Prehisoric Plant Based Origin Material With Ionic Minerals and Constituents

Highly Conductive/Full of Extra Electrons

Is a Full Spectrum Complex

Our Humic and Fulvic Liquid Trace Mineral Complex has Minerals, Amino Acids, Poly Electrolytes, Phytochemicals, Polyphenols, Bioflavonoids and Trace Vitamins included with the Humic and Fulvic Acid. Our Source material is high in these constituents, where other manufacturers use inferior materials.

Try Our Humic and Fulvic Liquid Trace Mineral Complex today. Order Yours Today by Following This Link.

Report abuse


    Your Comments
    Question   Razz  Sad   Evil  Exclaim  Smile  Redface  Biggrin  Surprised  Eek   Confused   Cool  LOL   Mad   Twisted  Rolleyes   Wink  Idea  Arrow  Neutral  Cry   Mr. Green

    Load more ...




    Email this story
    Email this story

    If you really want to ban this commenter, please write down the reason:

    If you really want to disable all recommended stories, click on OK button. After that, you will be redirect to your options page.