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LexaGene successfully configures its MiQLab system to detect mutant sequences unique to UK and South African coronavirus variants

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LexaGene Holdings Inc (CVE:LXG) (OTCQB:LXXGF) (FRA:5XS2) announced Wednesday it has successfully configured a MiQLab system to detect mutant sequences unique to the UK (B.1.1.7) and South African (B.1.351) variants of SARS-CoV-2, the coronavirus pathogen that causes the COVID-19 disease. 

The UK variant, known to be more contagious and possibly deadlier, was first detected in the US at the end of December and has now been identified in 33 states.  Likewise, both the South African and Brazilian variants were first detected in the US at the end of January, and several cases have now been reported in the US – suggesting more widespread infections.  

LexaGene said the UK, SA, and Brazilian variants have now acquired mutations that may likely reduce the efficacy of approved vaccines and therapeutics. 

READ: LexaGene Holdings initiates program to identify the UK and South African variants of coronavirus

The company’s MiQLab is designed for point-of-care use and for simultaneous screening of numerous respiratory pathogens, including COVID-19 strain identification. The system is open-access, which allows for new tests to be easily loaded onto the system. This is a unique feature that is not found in any other system designed for point-of-care use.

“Just three weeks ago, we designed assays to detect the UK and SA variants to demonstrate proof-of-principle that these assays could be quickly ported onto the MiQLab,” said Dr Jack Regan, LexaGene’s CEO and founder, in a statement.

“After just two full work days of having these reagents in-house, we verified our MiQLab could detect mutations associated with these variants. With proper FDA approvals, these tests could quickly be sent to MiQLabs operating at the point-of-care for faster detection, which would likely improve containment efforts for the spread of these new variants.”

Dr Regan added: “The optimism over the increasing availability of COVID-19 vaccines needs to be tempered with the worrisome potential that some of these new variants are not only more contagious, but also may render these vaccines less effective. Generally, getting a new vaccine authorized for use by FDA takes six or more months, so we really need to rely on better diagnostics to stop the spread of these new variants before they become more widespread and nearly impossible to contain. MiQLab’s open-access design allows the system to be quickly configured to detect new variants at the point-of-care. As such, our technology fills a critical testing gap we have in our defenses against these ever-changing pathogens.”

LexaGene is pursuing an Emergency Use Authorization (EUA) from the US Food and Drug Administration for COVID-19 testing using assays that are predicted to detect 99.9% of the strains circulating today based on published sequences – including the UK, South Africa, and Brazilian variants. 

At this time, LexaGene said it has no plans to incorporate the variant-specific tests into the initial FDA studies for EUA for COVID-19 testing.

As is standard practice, until the FDA grants LexaGene’s instrument EUA for COVID-19 testing, all work using LexaGene instruments is classified as Research Use Only and cannot be used for human clinical diagnostics. 

Contact the author: [email protected]

Follow him on Twitter @PatrickMGraham

Story by ProactiveInvestors


Source: http://www.proactiveinvestors.com/companies/news/940949/lexagene-successfully-configures-its-miqlab-system-to-detect-mutant-sequences-unique-to-uk-and-south-african-coronavirus-variants-940949.html


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