The biotech revealed it had been granted Mitacs Accelerate program funding for its joint application with Dr Argel Aguilar-Valles at Carleton University department of neuroscience to carry out research of the drug in preclinical models.
READ: BetterLife Pharma says early positive in vitro results show AP-003 has similar potent efficacy against coronavirus variants
Dr Argel Aguilar-Valles’s team, who are experts on the molecular mechanisms that underlie psychiatric and neurodevelopmental disorders, will work with BetterLife to test TD-010 in both in vitro and in vivo models that are established in the former’s lab.
“TD-010 is a potential novel therapy to treat debilitating anxiety disorders that show resistance to benzodiazepine and other therapies or require a long-term use and therefore put patients at risk for dependency,” said Betterlife CEO Dr Ahmad Doroudian in a statement.
“BetterLife’s goal is to bring this treatment to the Investigational New Drug (IND) application and the clinic as soon as possible because it is non-addictive yet potentially highly effective.”
Dr Argel Aguilar-Valles added: “We are delighted to have the opportunity to examine TD-010 in our established animal anxiety models. The high rate of resistance to benzodiazepine and SSRIs for chronic anxiety disorder indicates an urgent unmet need for alternative anxiolytic treatments.
“TD-010 has shown to have more potent anxiolytic effects than its parent compound honokiol and it can be a promising alternative in the treatment of chronic anxiety.”
TD-010 or dihydrohonokiol-B (DHH-B) is a compound that BetterLife is developing primarily for benzodiazepine dependency in addition to anxiety.
Each year, up to 20% of adults are affected by anxiety disorders and among the most used anxiolytic therapeutics are benzodiazepines, which from mid-February to mid-March, 2020 saw a 34% increase in prescriptions.
But Benzodiazepines have drawbacks, including a high rate of treatment resistance, dependence and serious side effects.
Contact the writer at [email protected]
Story by ProactiveInvestors
Please Help Support BeforeitsNews by trying our Natural Health Products below!
Order by Phone at 888-809-8385 or online at https://mitocopper.com M - F 9am to 5pm EST
Order by Phone at 888-388-7003 or online at https://www.herbanomic.com M - F 9am to 5pm EST
Order by Phone at 888-388-7003 or online at https://www.herbanomics.com M - F 9am to 5pm EST
Humic & Fulvic Trace Minerals Complex - Nature's most important supplement! Vivid Dreams again!
HNEX HydroNano EXtracellular Water - Improve immune system health and reduce inflammation
Ultimate Clinical Potency Curcumin - Natural pain relief, reduce inflammation and so much more.
pathogens and gives you more
energy. (See Blood Video)
Oxy Powder - Natural Colon Cleanser! Cleans out toxic buildup with oxygen!
Nascent Iodine - Promotes detoxification, mental focus and thyroid health.
Smart Meter Cover - Reduces Smart Meter radiation by 96%! (See Video)
Immusist Beverage Concentrate - Proprietary blend, formulated to reduce inflammation while hydrating and oxygenating the cells.