Corexit and A Second product Sea Brat4 Endocrine disruptor

CNN-BP Refuses To Use Safer Dispersant Sea Brat Opting For Toxic Corexit

Endocrine system

From Wikipedia, the free encyclopedia

In physiology, the endocrine system is a system of glands, each of which secretes a type of hormone directly into the bloodstream to regulate the body. The endocrine system is in contrast to exocrine system, which secretes its chemicals using ducts. It derives from the Greek words endo (Greek ένδο) meaning inside, within, and crinis (Greek κρινής) for secrete. The endocrine system is an information signal system like the nervous system, yet its effects and mechanism are classifiably different. The endocrine systems effects are slow to initiate, and proglonged in their response, lasting for hours to weeks. The nervous system sends information very quickly, and responses are generally short lived. Hormones are substances (chemical mediators) released from endocrine tissue into the bloodstream where they travel to target tissue and generate a response. Hormones regulate various human functions, including Metabolism, growth and development, tissue function, and mood. The field of study dealing with the endocrine system and its disorders is endocrinology, a branch of internal medicine.

Features of endocrine glands are, in general, their ductless nature, their vascularity, and usually the presence of intracellular vacuoles or granules storing their hormones. In contrast, exocrine glands, such as salivary glands, sweat glands, and glands within the gastrointestinal tract, tend to be much less vascular and have ducts or a hollow lumen.

In addition to the specialised endocrine organs mentioned above, many other organs that are part of other body systems, such as the kidney, liver, heart and gonads, have secondary endocrine functions. For example the kidney secretes endocrine hormones such as erythropoietin and renin.

The endocrine system is made up of a series of glands that produce chemicals called hormones. A number of glands that signal each other in sequence is usually referred to as an axis, for example, the hypothalamic-pituitary-adrenal axis.

Major endocrine systemsThe human endocrine system consists of several systems that operate via feedback loops. Several important feedback systems are mediated via the hypothalamus and pituitary.[12]

TRH – TSH – T3/T4

GnRH – LH/FSH – sex hormones

CRH – ACTH – cortisol

Renin – angiotensin – aldosterone

[edit] Diseases

Disability-adjusted life year for endocrine disorders per 100,000 inhabitants in 2002.[13]

Diseases of the endocrine system are common,[14] including conditions such as diabetes mellitus, thyroid disease, and obesity. Endocrine disease is characterized by disregulated hormone release (a productive pituitary adenoma), inappropriate response to signaling (hypothyroidism), lack of a gland (diabetes mellitus type 1, diminished erythropoiesis in chronic renal failure), or structural enlargement in a critical site such as the thyroid (toxic multinodular goitre). Hypofunction of endocrine glands can occur as a result of loss of reserve, hyposecretion, agenesis, atrophy, or active destruction. Hyperfunction can occur as a result of hypersecretion, loss of suppression, hyperplastic or neoplastic change, or hyperstimulation.

Endocrinopathies are classified as primary, secondary, or tertiary. Primary endocrine disease inhibits the action of downstream glands. Secondary endocrine disease is indicative of a problem with the pituitary gland. Tertiary endocrine disease is associated with dysfunction of the hypothalamus and its releasing hormones.[citation needed]

As the thyroid, and hormones have been implicated in signaling distant tissues to proliferate, for example, the estrogen receptor has been shown to be involved in certain breast cancers. Endocrine, paracrine, and autocrine signaling have all been implicated in proliferation, one of the required steps of oncogenesis.[15]

Other types of signalingThe typical mode of cell signaling in the endocrine system is endocrine signaling. However, there are also other modes, i.e., paracrine, autocrine, and neuroendocrine signaling.[16] Purely neurocrine signaling between neurons, on the other hand, belongs completely to the nervous system.

[edit] AutocrineMain article: Autocrine signalling

Autocrine signaling is a form of signaling in which a cell secretes a hormone or chemical messenger (called the autocrine agent) that binds to autocrine receptors on the same cell, leading to changes in the cells.

[edit] ParacrineMain article: Paracrine signalling

Paracrine signaling is a form of cell signaling in which the target cell is near the signal-releasing cell.

[edit] JuxtacrineMain article: Juxtacrine signalling

juxtacrine signaling is a type of intercellular communication that is transmitted via oligosaccharide, lipid, or protein components of a cell membrane, and may affect either the emitting cell or the immediately adjacent cells.

It occurs between adjacent cells that possess broad patches of closely opposed plasma membrane linked by transmembrane channels known as connexons. The gap between the cells can usually be between only 2 and 4 nm.

Unlike other types of cell signaling (such as paracrine and endocrine), juxtacrine signaling requires physical contact between the two cells involved.

Juxtacrine signaling has been observed for some growth factors, cytokine and chemokine cellular signals

http://en.wikipedia.org/wiki/Endocrine_system

“Endocrine disruptor”

From Wikipedia,

Endocrine disruptors are exogenous substances usually xenoestrogens that “interfere with the synthesis, secretion, transport, binding, action, or elimination of natural hormones in the body that are responsible for the maintenance of homeostasis (normal cell metabolism), reproduction, development, and/or behavior.”[1] They are sometimes also referred to as hormonally active agents,[2] endocrine disrupting chemicals,[3] or endocrine disrupting compounds (EDCs).[4]

EDC studies have linked endocrine disruptors to adverse biological effects in animals, giving rise to concerns that low-level exposure might cause similar effects in human beings.[5]

In this paper, she stated that environmental chemicals disrupt the development of the endocrine system, and that effects of exposure during development are permanent. Although the theory of endocrine disruption has been disputed by some,[7] work sessions from 1992 to 1999 have generated consensus statements from scientists regarding the hazard from endocrine disruptors, mostly in wildlife but also in humans.[8][9][10][11][12] In a 2003 article it was uncertain whether the endocrine disruption seen in animals from relatively high doses implies that humans would suffer adverse effects from normally much less exposure, and this needed to be investigated.[13] In 2009 The Endocrine Society released a scientific statement outlining mechanisms and effects of endocrine disruptors on “male and female reproduction, breast development and cancer, prostate cancer, neuroendocrinology, thyroid, metabolism and obesity, and cardiovascular endocrinology,” and showing how experimental and epidemiological studies converge with human clinical observations “to implicate EDCs as a significant concern to public health.” However, the statement noted that it is difficult to show that endocrine disruptors cause human diseases. It recommended that the precautionary principle should be followed.[3] A concurrent statement expresses policy concerns.[14]

Endocrine disrupting compounds encompass a variety of chemical classes, including hormones, plant constituents, pesticides, compounds used in the plastics industry and in consumer products, and other industrial by-products and pollutants. Some are pervasive and widely dispersed in the environment. Some are persistent organic pollutants (POP’s), and can be transported long distances across national boundaries and have been found in virtually all regions of the world. Others are rapidly degraded in the environment or human body or may be present for only short periods of time.[15] Health effects attributed to endocrine disrupting compounds include a range of reproductive problems (reduced fertility, male and female reproductive tract abnormalities, and skewed male/female sex ratios, loss of fetus, menstrual problems[16]); changes in hormone levels; early puberty; brain and behavior problems; impaired immune functions; and various cancers.[17]

One example of the consequences of the exposure of developing animals, including humans, to hormonally active agents is the case of the drug diethylstilbestrol (DES), a non-steroidal estrogen and not an environmental pollutant. Prior to its ban in the early 1970s, doctors prescribed DES to as many as five million pregnant women to block spontaneous abortion, an off-label use of this medication prior to 1947. It was discovered after the children went through puberty that DES affected the development of the reproductive system and caused vaginal cancer. The relevance of the DES saga to the risks of exposure to endocrine disruptors is questionable, as the doses involved are much higher in these individuals than in those due to environmental exposures.[18

http://en.wikipedia.org/wiki/Endocrine_disruptor

April 2, 2011 at 10:48 pm

Endocrine systems are found in most varieties of animals. The endocrine system consists of glands that secrete hormones, and receptors that detect and react to the hormones.

Hormones travel throughout the body and act as chemical messengers. Hormones interface with cells that contain matching receptors in or on their surfaces. The hormone binds with the receptor, much like a key would fit into a lock. The endocrine system regulates adjustments through slower internal processes, using hormones as messengers. The endocrine system secretes hormones in response to environmental stimuli and to orchestrate developmental and reproductive changes. The adjustments brought on by the endocrine system are biochemical, changing the cell’s internal and external chemistry to bring about a long term change in the body. These systems work together to maintain the proper functioning of the body through its entire life cycle. Sex steroids such as estrogens and androgens, as well as thyroid hormones, are subject to feedback regulation, which tends to limit the sensitivity of these glands.

The theory of endocrine disruption posits that low-dose exposure to chemicals that interact with hormone receptors can interfere with reproduction, development, and other hormonally mediated processes. Furthermore, since endogenous hormones are already present in the body in biologically active concentrations, the theory holds that additional exposure to relatively small amounts of exogenous hormonally active substances can disrupt the proper functioning of the body’s endocrine system. Thus, an endocrine disruptor might be able to elicit adverse effects at a much lower doses than a toxicant acting through a different mechanism.

The timing of exposure is also presumed to be critical, since different hormone pathways are active during different stages of development. Particularly with younger individuals that are growing rapidly, interfering with the hormonal communication processes these systems provide can have profound effects on the body. Depending on the stage of reproductive development, interference with hormonal signaling can result in irreversible effects not seen in adults exposed to the same dose for the same length of time.[19][20][21] Experiments with animals have identified critical developmental time points in utero and days after birth when exposure to chemicals that interfere with or mimic hormones have adverse effects that persist into adulthood.[20][22][23][24] Disruption of thyroid function early in development may be the cause of abnormal sexual development in both males[25] and females[26] early motor development impairment,[27] and learning disabilities.[28]

There are studies of cell cultures, laboratory animals, wildlife, and accidentally exposed humans that show that environmental chemicals cause a wide range of reproductive, developmental, growth, and behavior effects, and so while “endocrine disruption in humans by pollutant chemicals remains largely undemonstrated, the underlying science is sound and the potential for such effects is real.”[29] While compounds that produce estrogenic, androgenic, antiandrogenic, and antithyroid actions have been studied, less is known about interactions with other hormones.

The interrelationship between exposures to chemicals and health effects are rather complex. It is hard to definitively link a particular chemical with a specific health effect, and exposed adults may not show any ill effects. But, fetuses and embryos, whose growth and development are highly controlled by the endocrine system, are more vulnerable to exposure and may suffer overt or subtle lifelong health and/or reproductive abnormalities.[30] Prebirth exposure, in some cases, can lead to permanent alterations and adult diseases.[31]

Some in the scientific community are concerned that exposure to endocrine disruptors in the womb or early in life may be associated with neurodevelopmental disorders including reduced IQ, ADHD, and autism.[32] Certain cancers and uterine abnormalities in women are associated with exposure to DES in the womb due to DES used a medical treatment.

In another case, phthalates in pregnant women’s urine was linked to subtle, but specific, genital changes in their male infants – a shorter, more female-like anal-genital distance and associated incomplete descent of testes and a smaller scrotum and penis.[33] The science behind this study has been questioned by phthalate industry consultants.[34] As of June 2008, there are only five studies of anogenital distance in humans,[35] and one researcher has stated “Whether AGD measures in humans relate to clinically important outcomes, however, remains to be determined, as does its utility as a measure of androgen action in epidemiologic studies.”[36]

http://en.wikipedia.org/wiki/Endocrine_disruptor

BP: We Have to Use Corexit Because No One Tests for Endocrine Disruptors

By: emptywheel Monday May 24, 2010 9:26 am

As Scarecrow reported on Saturday, BP told EPA it would not switch from Corexit to another less toxic dispersant. BP admits that five approved dispersants are less toxic than Corexit; it dismisses four of those because the manufacturers cannot get enough product in place immediately.

BP does not have a stockpile of the other dispersants that meet the criteria in the May 19th Directive [of being less toxic], and the manufacturers tell us that they cannot produce the requested volume for 10 to 14 days or more.

So what about the fifith dispersant, Sea Brat #4, which is both less toxic and–BP tells us–and which BP has 100,000 gallons in its inventory? BP explains that Sea Brat #4 may degrade into an endocrine disruptor.

Sea Brat #4 contains a small amount of a chemical that may degrade to a nonylphenol (NP). The class of NP chemicals have been identified by various government agencies as potential endocrine disruptors, and as chemicals that may persist in the environment for a period of years. The manufacturer has not had the opportunity to evaluate this product for these potential effects, and BP has not had the opportunity to conduct independent tests to evaluate this issue either. BP learned of this issue after it applied to use Sea Brat #4 at the incident site.

With this additional information in hand, we believe it would be prudent to evaluate the potential NP issue more carefully before EPA or the FOSC require Sea Brat to be used at the incident site, and in particular, before it is applied underwater near….

http://emptywheel.firedoglake.com/2010/05/24/bp-we-have-to-use-corexit-because-no-one-tests-for-endocrine-disruptors/

==

SEA-BRAT#4

For the Dispersion and Clean Up of water pollution and hydrocarbon oil spills. Applied to any hydrocarbon it will disperse the oil spill on contact. It’s that simple. SEA BRAT was designed as an environmentally friendly alternative to the hazardous chemical dispersants currently used for water pollution. This product will disperse hydrocarbons in the extreme providing for or to the point of more rapid biodegradation. SEA BRAT is Extremely Effective if used with microbial or bioremediation product.

Alabaster Bioremediation Corp.

6921 Olson

Pasadena, Texas 77505

http://www.environmental-expert.com/stse_resulteach_product.aspx?cid=992&idproduct=41405&codi=41405

SEA BRAT #4

TECHNICAL PRODUCT BULLETIN #D-10

USEPA, OIL PROGRAM CENTER

ORIGINAL LISTING DATE: NOVEMBER 26, 2002

REVISED LISTING DATE:

“SEA BRAT #4″

http://www.epa.gov/oem/content/ncp/products/seabrat4.htm

BP: We Have to Use Corexit Because No One Tests for Endocrine Disruptors

By: emptywheel Monday May 24, 2010 9:26 am

As Scarecrow reported on Saturday, BP told EPA it would not switch from Corexit to another less toxic dispersant. BP admits that five approved dispersants are less toxic than Corexit; it dismisses four of those because the manufacturers cannot get enough product in place immediately.

BP does not have a stockpile of the other dispersants that meet the criteria in the May 19th Directive [of being less toxic], and the manufacturers tell us that they cannot produce the requested volume for 10 to 14 days or more.

So what about the fifith dispersant, Sea Brat #4, which is both less toxic and–BP tells us–and which BP has 100,000 gallons in its inventory? BP explains that Sea Brat #4 may degrade into an endocrine disruptor.

Sea Brat #4 contains a small amount of a chemical that may degrade to a nonylphenol (NP). The class of NP chemicals have been identified by various government agencies as potential endocrine disruptors, and as chemicals that may persist in the environment for a period of years. The manufacturer has not had the opportunity to evaluate this product for these potential effects, and BP has not had the opportunity to conduct independent tests to evaluate this issue either. BP learned of this issue after it applied to use Sea Brat #4 at the incident site.

With this additional information in hand, we believe it would be prudent to evaluate the potential NP issue more carefully before EPA or the FOSC require Sea Brat to be used at the incident site, and in particular, before it is applied underwater near….

http://emptywheel.firedoglake.com/2010/05/24/bp-we-have-to-use-corexit-because-no-one-tests-for-endocrine-disruptors/

Sea Brat4 MSDS.pdf 108kb

http://www.alabastercorp.com/Sea%20Brat4%20MSDS.pdf

SEA BRAT is a powerful Emergency Response Dispersant! For the Dispersion and Clean Up of Ocean Oil Spills and Water Pollution. Applied to any Hydrocarbon Fuel Spill or Oil Spill it will Disperse the Spill on Contact! It’s that simple. This product will disperse hydrocarbons in the extreme providing for or to the point of more rapid biodegradation. SEA BRAT was designed specifically for use as an environmentally friendly oil spill dispersant for ocean pollution and water pollution.

==

Sea Brat: Oil Spill Remedy that BP Is Trying to Deny

By: johnnydiamond Tuesday May 25, 2010 10:08 pm

I make Sea Brat. The thing that has been tricky to explain is that all of our products were made for bioremediation. We mix a liquid blend of enzymes and oil eating microbes. These microbes are formulated just for these hydrocarbons. They are basically typical, natural microbes or psudomonas. They are aerobic meaning they use oxygen. These are basically fed only hydrocarbon chains until they develop the enzymes necessary to metabolize the hydrocarbon. But this has been tricky…

First the EPA has a system set up where after testing (expensive for small companies like us) a product can only be classified within 1 of the product catagories. There are 4 catagories. (Dispersant, Surface Cleaning Agent, Bioremediation, Miscellaneous which is typicaly booms, absorbants or silly trick products). However, EPA will only allow a product to be within 1 catagory at a time. So if I have a qualified bioremediation product it would be in that catagory. Which means I can not be in the “dispersant” catagory. Therefore I can not be used in this event.

This in my opinion is more….

I needed a “dispersant” in order to provide for an oceanic oil spill. So they ignore or disallow me to advertise the microbial aspect. Same with Petro Clean. Petro Clean was designed to render flammable spills non flammable. Firemen are my main customers with PC. However, PC was designed specifically to bioremediate the contamination. You have a gasoline or diesel spill and PC prevents fire and explosion AND treats the washed off contamination. But EPA does not allow me to directly advertise this.

So if I added these in the EPA “bioremediation” catagory I would not be able to use them on anything but soil cleanup. ???….

http://my.firedoglake.com/johnnydiamond/2010/05/25/sea-brat-oil-spill-remedy-that-bp-is-trying-to-deny/

Scientists grapple with BP oil spill’s cost to bird life

By Rick Jervis, USA TODAY

NEW ORLEANS — Pictures of pelicans slathered in oil during last summer’s BP oil disaster became iconic images of the event…..

The official count is 8,065 live and dead birds affected by the spill, according to U.S. Fish and Wildlife Service reports. That number includes 932 pelicans and 3,300 laughing gulls, the reports show…..

http://www.usatoday.com/news/nation/environment/2011-04-01-oilbirds01_ST_N.htm

Portland documentary filmmaker tracks a pelican oiled in last year’s Gulf spill

Friday, April 01, 2011

The resulting 40-minute documentary, “Saving Pelican 895,” makes its HBO debut on April 20, the first anniversary of the night an explosion ripped through the Deepwater Horizon rig.

http://www.oregonlive.com/portland/index.ssf/2011/04/portland_documentary_filmmaker.html

Ga. pelicans rescued from Gulf oil spill return for nesting season; survival still in question

RUSS BYNUM Associated Press

First Posted: April 01, 2011

Aransas National Wildlife Refuge on the Texas coast, where 172 rescued brown pelicans were released last year. “They’re clean, <<<(((but a lot of them have suffered internal organ damage from ingesting the oil.”)))<<<<…

<<<(((The success birds on the Gulf coast have making babies could yield clues to whether the fish they eat and the water they drink have recovered or remain polluted.)))<<<<

Some pelicans with bands identifying them…

http://www.therepublic.com/view/story/0812b18708e346999db0c6829ff833ea/US–Gulf-Oil-Spill-Pelicans/

Pelicans saved from Gulf oil stick to new homes

RUSS BYNUM, Associated Press

Updated 05:52 p.m., Friday, April 1, 2011

And just because they survived the winter doesn’t necessarily mean they escaped harm altogether.

“In general, the prognosis for oiled birds is not good — you can’t expect survival rates to be extremely high,” said Tom Stehn, a wildlife biologist at the Aransas National Wildlife Refuge on the Texas coast, where 172 rescued brown pelicans were released last year. “They’re clean, “>>>((but a lot of them have suffered internal organ damage from ingesting the oil))”.”<<<<

http://www.beaumontenterprise.com/news/article/Pelicans-saved-from-Gulf-oil-stick-to-new-homes-1318199.php

Petroleum Oil (Chemical Page)

Up to 10% of crude oil consists of aromatics, which are volatile cyclic compounds. ….. of Kuwait crude (22% aromatics) failed to put on weight in the eight to …. blood disorders in Mus domesticus – Laboratory mouse and blood disorders ….. lesions commonly

result from petroleum; increasing concentrations cause …

http://wildlife1.wildlifeinformation.org/s/00Chem/ChComplex/Petroleum.htm

—

“Yana Curi” Report

oil can cause lesions in various organs, and can provoke birth defects, cancer, ….. statistically more convincing analysis that could put in evidence other ….. Bay crude oil; effet on mouse liver weigh and composition. Toxicology …

http://chevrontoxico.com/assets/docs/yana-curi-eng.pdf

—

crude oil cause lesions and more

Histopathologic Lesions in Sea Otters Exposed to Crude Oil

histopathologic lesions associated with crude oil ex- posure in sea otters and to di scuss ….. No vascular lesions or other causes were evident. This pattern was found in animals that died after … and toxicology protocols were eventually put in use, ….. chronic inhalation toxicity of benzene in rats and mice.

http://vet.sagepub.com/content/30/1/1.full.pdf

—

BP Dispersants Causing Sickness | Health Freedom Alliance

7 Nov 2010 … Nearly 200000000 gallons of crude oil spilled into the Gulf of Mexico due to the … respiratory problems, neurological problems, lesions, sores, and ulcers. … Mouse-Pig & Super-Fish Seek Approval for Human Consumption … worth of raw cheese and a court battle that has put Morningland Dairy, …

http://healthfreedoms.org/2010/11/07/bp-dispersants-causing-sickness/

—

crude oil cause lesions and more

Histopathologic Lesions in Sea Otters Exposed to Crude Oil

histopathologic lesions associated with crude oil ex- posure in sea otters and to di scuss ….. No vascular lesions or other causes were evident. This pattern was found in animals that died after … and toxicology protocols were eventually put in use, ….. chronic inhalation toxicity of benzene in rats and mice.

http://vet.sagepub.com/content/30/1/1.full.pdf

—

Petroleum Oil (Chemical Page)

Up to 10% of crude oil consists of aromatics, which are volatile cyclic compounds. …..

of Kuwait crude (22% aromatics) failed to put on weight in the eight to …. blood

disorders in Mus domesticus – Laboratory mouse and blood disorders ….. lesions commonly

result from petroleum; increasing concentrations cause …

http://wildlife1.wildlifeinformation.org/s/00Chem/ChComplex/Petroleum.htm

xdrfox

It is my belief that many of these mammals and others including turtles may have lesions that are inside their ingestion track, possibly elsewhere in their bodies as well as outside bleeding lesions ! Are these lesions malignant or benign ?

Is it possible that these are cause by crude products and/or Corexit and or other products introduced into the Gulf and have also has been/will be showing up in the humans as hard to heal lesions ? Or is it that humans can take some what care of early surface lesions to where they are not able to grow/change/manifest unhampered and or is staying in the Gulf as it is, is allowing these mammals lesions to grow unabated ?

Can you Folks see the huge lesion on the left side of this calfs face/head ?

Fish with lesions are coming up every catch, fishermen from Pensacola and Panama City say

http://www.floridaoilspilllaw.com/fish-lesions-coming-every-catch-fishermen-pensacola-

http://www.courthousenews.com/2011/03/30/35363.htm … “since February 2010, 2 months before the disastrous oil spill, dolphins have been dying at unusually high rates.

The first report of cracks in the both rocks surrounding the well and in the well itself “in February” was only the first in a series of “well control events” or blowouts.

Since the initial February blowout, according to the findings of an interim investigation released by congress there have been a total of 5 “well control events” or blowouts including the final blowout that led to the Deepwater Horizon rig explosion and collapse.

http://blog.alexanderhiggins.com/2010/06/28/ixtoc-oil-spill-undeground-blowout-caused-oil-leak-cracks-seafloor-1822/

BP may have even waited a period of time before reporting the well misshapes, possibly weeks or more depending on the leaks size and what they felt they could contain or hide without reporting. But after they saw it would be found out or was found out by authorities made the records at MMS. Common practice in the oil industry as we have been reading about in recent non producing well and platform spills.

Necropsy’s on the early dolphin deaths may have reveled a possible connection at the time and and this may have been consistent with dolphins this year showing a pattern and a connection to oil or/and corexit use and leading to court actions of late ?

http://www.floridaoilspilllaw.com/dead-baby-dolphin-washes-florida-indicates-about-environments-health-expert-video/comment-page-1#comment-147687

Look for Corexit in the Military after 1989

Were you in the military since July, 1989?

The military bought Corexit 9527? Corexit 9527 has 38% 2-butoxyethanol and some ethylene oxide (causes pulmonary edema) … lungs fill up with fluid. perpetual GWS? beginning of GWS?