Tryptophan depletion affects heart rate
Home of Kyle J. Norton for The Better of Living & Living Health Serotonin or 5-hydroxytryptamine (5-HT) is a monoamine neurotransmitter derived from tryptophan, primarily found in the gastrointestinal (GI) tract, platelets, and in the central nervous system (CNS). In Gut, serotonin regulates intestinal movements, in CNS, it regulates mood, appetite, sleep, memory and learning, etc,.
Tryptophan depletion affects heart rate
In a a randomized, counterbalanced, double-blind crossover design study, nineteen patients in remission from depression received high-dose and low-dose acute tryptophan depletion, found that high-dose acute tryptophan depletion led to a larger increase in depressive symptoms than did low-dose acute tryptophan depletion. High-dose acute tryptophan depletion decreased heart rate variability and increased impulsivity and anxiety, but only in patients with a history of suicidal ideation. Symptom effects of high-dose acute tryptophan depletion correlated with low heart rate variability at baseline(38).
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(38) http://www.ncbi.nlm.nih.gov/pubmed/16603135 http://medicaladvisorjournals.blogspot.com
2012-12-31 18:48:29
Source: http://medicaladvisorjournals.blogspot.com/2012/12/tryptophan-depletion-affects-heart-rate.html
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This article’s introduction reinforces the idea, along with its allegedly supporting study reference, that an adequate amount or surplus of tryptophan -thus sufficient or high levels of serotonin- equates to or leads to happiness or non-depression. But tryptophan and melatonin, an end product of trytophan/serotonin, has been shown to augment depression, and many non-suicidal people have become suicidal upon the consumption of serotonin-activating drugs (review http://www.supplements-and-health.com/tryptophan-side-effects.html ).