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Dietary Sulfur - Diallyl disulfide (DADS)(Organosulfides) and cervical cancer

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Home of Kyle J. Norton for The Better of Living & Living Health Sulfur represents approximately 1/4% of our total body weight and occurs principally in the body as a constituent of the cysteine and methionine. It plays an important role in protein synthesis and enzyme reaction functions and is found abundantly in broccoli, cauliflower, cabbage, kale, kohlrabi, etc.
 Organosulfides
Organosulfur compounds present in natural food are generally considered as beneficial for health because of their antioxidant and anticarcinogenic properties. This has led to their excessive and long-term consumption. However, there is also evidence that these compounds demonstrate toxicity and adverse health effects suggesting their potential dual biological roles. Thus, they can act as double-edged biological swords(a).
Diallyl disulfide and Trisulfide, S-allylcysteine (SAC)  are organosulfur compounds derived from garlic and a few other genus Allium, such as onions, garlic, chives, and leeks, etc.
Diallyl disulfide (DADS) and cervical cancer
According to the study of the mechanisms of apoptosis induced by diallyl disulfide (DADS) were explored in human cervical cancer Ca Ski cells, researchers at the Jen-Teh Junior College of Medicine showed that DADS induced apoptosis through the production of reactive oxygen species and Ca2+, and induced abrogation of mitochondrial membrane potential (Deltapsim) and cleavage of Bid protein (t-Bid). DADS increased the levels of p53, p21 and Bax, but caused a decrease in the level of Bcl-2. DADS also promoted the activities of caspase-3 leading to DNA fragmentation, thus indicating that DADS-induced apoptosis is caspase-3 dependent. In addition, DADS induced an increase in the level of cytochrome c in the cytoplasm, which was released from mitochondria. BAPTA attenuated the Deltapsim abrogation and significantly diminished the occurrence of DADS-induced apoptosis in Ca Ski cells(17).

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Sources  
(17) http://www.ncbi.nlm.nih.gov/pubmed/19035312 http://medicaladvisorjournals.blogspot.com

2013-01-22 18:20:05

Source: http://medicaladvisorjournals.blogspot.com/2013/01/diallyl-disulfide-dads-and-cervical.html



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