Adiponectin and its role in the pathogenesis of obesity, diabetes mellitus and insulin resistance
Home of Kyle J. Norton for The Better of Living & Living Health Adiponectin
A protein hormone encoded by the ADIPOQ gene and produced and secreted exclusively by adipocytes with the function of of regulating the metabolism of lipids and glucose(a)(b).
Adiponectin and its role in the pathogenesis of obesity, diabetes mellitus and insulin resistance
In the review of the structure and role of adiponectin in the regulation of metabolic balance, showed that Adiponectin is the most abundant adipocytokine that is produced exclusively in the fat tissue. Its high concentration protects from diabetes mellitus, atherosclerosis and insulin resistance, its low concentration increases the risk of these disorders. The adiponectin gene is one of the many candidate genes in type 2 diabetes. Adiponectin binds to two types of receptors: 1 and 2, encoded by two genes: AdipoR1, and AdipoR2, respectively. The receptors are found in all tissues, with type 1 predominant in the muscles, and type 2 in the liver. Most importantly, the role of adiponectin in the body and the results of animal model experiments suggest the possible future use of adiponectin in the treatment of diabetes, atherosclerosis and obesity(4).
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Sources
(a) http://www.medterms.com/script/main/art.asp?articlekey=17982
(b) http://en.wikipedia.org/wiki/Adiponectin
(4) http://www.ncbi.nlm.nih.gov/pubmed/16780274 http://medicaladvisorjournals.blogspot.com
Source: http://medicaladvisorjournals.blogspot.com/2013/09/adiponectin-and-its-role-in.html
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