Adiponectin gene expression and adipocyte NF-kappaB transcriptional activity in elderly overweight and obese women

Home of Kyle J. Norton for The Better of Living & Living Health Adiponectin
A protein hormone encoded by the ADIPOQ gene and produced and secreted exclusively by adipocytes with the function of of  regulating the metabolism of lipids and glucose(a)(b).
Adiponectin gene expression and adipocyte NF-kappaB transcriptional activity in elderly overweight and obese women
In the study to evaluate of a total of 27 women aged between 50 and 80 years, with BMI ranging from 22.1 to 53.3 kg/m(2), with the examination of all subjects BMI, waist circumference, body composition by dual X-ray absorptometry, triglycerides, cholesterol, high-density lipoprotein cholesterol (HDL-Ch), glucose, insulin, homeostasis model assessment of insulin resistance (HOMA), high-sensitive C-reactive protein (hs-CRP), serum adiponectin, leptin and TNF-alpha, showed that BMI and waist circumference were associated positively with leptin, HOMA, and hs-CRP, and negatively with HDL-Ch; waist was also associated with adiponectin and IkB-alpha mRNA. HOMA was negatively associated with serum adiponectin and adiponectin mRNA. Hs-CRP was negatively associated with IkB-alpha mRNA, and was positively associated with HOMA. Step-down multiple regression analysis was performed to determine the joint effects of BMI, waist circumference, triglycerides, HDL-Ch, HOMA, hs-CRP, leptin, serum and TNF-alpha mRNA on adiponectin gene expression: waist circumference and leptin were both included in the best fitting regression equation for predicting adiponectin gene expression (R(2)=0.403, P=0.006). Stepwise multiple regression analysis was performed, considering IkB-alpha mRNA as a dependent variable and BMI, waist, HDL-Ch, HOMA, hs-CRP and adiponectin mRNA as independent variables. Adiponectin mRNA was the only variable to enter the regression (R(2)=0.406, P<0.001)(8).
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Sources
(a) http://www.medterms.com/script/main/art.asp?articlekey=17982 
(b) http://en.wikipedia.org/wiki/Adiponectin     
(8) http://www.ncbi.nlm.nih.gov/pubmed/17325687 http://medicaladvisorjournals.blogspot.com