Read the Beforeitsnews.com story here. Advertise at Before It's News here.

By Renal Fellow Network (Reporter)
Contributor profile | More stories

Story Views
Now:
Last hour:
Last 24 hours:
Total:

Type B Lactic Acidosis

Tuesday, October 8, 2013 13:04

% of readers think this story is Fact. Add your two cents.

Nice case report in AJKD recently raised the issue of Type B Lactic Acidosis. Lactic acidosis occurs when there is excessive anaerobic glycolysis or decreased removal of lactate from the circulation. Classically, Type A lactic acidosis is related to tissue hypoperfusion resulting in an increase in anaerobic glycolysis. Type B lactic acidosis occurs despite the presence of sufficient oxygen for aerobic glycolysis. There are a number of important causes:

Drugs/Toxins	Metformin Linezolid Propofol Nucleoside Reverse Transcriptase Inhibitors Salicylates Isoniazid Alcohol Cyanide
Enzyme Deficiencies	Glucose-6-phosphatase Pyruvate carboxylate Pyruvate Dehydrogenase Oxidative Phosphorylation Defects
Other Disorders	Kidney Failure Liver Failure Thiamine Deficiency Malignancy

The case report in AJKD was a patient with myeloma who developed a severe lactic acidosis. The preference of tumor cells for anaerobic glycolysis has been known since the 1920s and is called the Warburg Effect. It is thought to be due to a combination of increased IGF and TGF-alpha production by tumor cells and thiamine deficiency which is common in patients with malignancies. The discussion in the case report gives a nice summary of the literature.

Source: http://renalfellow.blogspot.com/2013/10/type-b-lactic-acidosis.html

Before It’s News® is a community of individuals who report on what’s going on around them, from all around the world.

Anyone can join.
Anyone can contribute.
Anyone can become informed about their world.

"United We Stand" Click Here To Create Your Personal Citizen Journalist Account Today, Be Sure To Invite Your Friends.

Humic & Fulvic Liquid Trace Mineral Complex

HerbAnomic’s Humic and Fulvic Liquid Trace Mineral Complex is a revolutionary New Humic and Fulvic Acid Complex designed to support your body at the cellular level. Our product has been thoroughly tested by an ISO/IEC Certified Lab for toxins and Heavy metals as well as for trace mineral content. We KNOW we have NO lead, arsenic, mercury, aluminum etc. in our Formula. This Humic & Fulvic Liquid Trace Mineral complex has high trace levels of naturally occurring Humic and Fulvic Acids as well as high trace levels of Zinc, Iron, Magnesium, Molybdenum, Potassium and more. There is a wide range of up to 70 trace minerals which occur naturally in our Complex at varying levels. We Choose to list the 8 substances which occur in higher trace levels on our supplement panel. We don’t claim a high number of minerals as other Humic and Fulvic Supplements do and leave you to guess which elements you’ll be getting. Order Your Humic Fulvic for Your Family by Clicking on this Link , or the Banner Below.

Our Formula is an exceptional value compared to other Humic Fulvic Minerals because...

It’s OXYGENATED

It Always Tests at 9.5+ pH

Preservative and Chemical Free

Allergen Free

Comes From a Pure, Unpolluted, Organic Source

Is an Excellent Source for Trace Minerals

Is From Whole, Prehisoric Plant Based Origin Material With Ionic Minerals and Constituents

Highly Conductive/Full of Extra Electrons

Is a Full Spectrum Complex

Our Humic and Fulvic Liquid Trace Mineral Complex has Minerals, Amino Acids, Poly Electrolytes, Phytochemicals, Polyphenols, Bioflavonoids and Trace Vitamins included with the Humic and Fulvic Acid. Our Source material is high in these constituents, where other manufacturers use inferior materials.

Try Our Humic and Fulvic Liquid Trace Mineral Complex today. Order Yours Today by Following This Link.

Comments

Online:
Visits:	1,615,510,256
Stories:	8,186,304