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Beware Of The 'Baboon Syndrome'

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Similar to The “Red man syndrome” (RMS), a commonly recognized adverse reaction of vancomycin administration, but the

” Baboon Syndrome” is far more rare and dangerous

A 40-year-old man with a sore throat and fever was diagnosed with tonsillitis, and was prescribed penicillin, a common antibiotic. But several days later, the man developed a rash over his armpits, groin and buttocks — an unusual condition known as “baboon syndrome.”

The condition, more formally called symmetrical drug-related intertriginous and flexural exanthema (SDRIFE), is known as baboon syndrome because the rash on the patient’s buttocks resembles the red hindquarters of some monkeys.
 

Baboon syndrome typically appears a few hours to two days after a person takes an antibiotic. The syndrome rarely affects small children, but cases have been reported in an 18-month-old and a 5-year-old, the researchers noted in their case report. Recovery can sometimes take up to three weeks. Exposure to penicillin, nickel or mercury are the most common causes of the syndrome, but it has also been linked to certain heartburn drugs, biological agents and chemotherapy.



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