Gout is a form of inflammatory arthritis mostly affecting joints of the periphery (feet, knees, hands, and elbows).1 The big toe is the most common and notorious site of acute gout attacks, and these attacks are extremely painful. Some have said the pain is on the same level of order as childbirth. Needless to say, gout is no fun ordeal to deal with.
With that being said, my goal is to help you understand how gout develops, and show you what you can do about it in order to prevent or treat it.
THE DEVELOPMENT OF GOUT
Gout results from a multi-step process that ultimately ends in the formation of uric acid crystals that are deposited into the joint spaces. Joint inflammation and pain then ensues leading to what is commonly called a ‘gout attack’.
Where do these uric acid crystals come from? And how do they form in the first place?
These questions are the most crucial to understand if you wish to rid yourself of gout or prevent it from occurring in the first place.
Uric acid crystals result from excessive amounts of uric acid in the blood, a condition known as hyperuricemia.2 Hyperuricemia develops when the body reaches a tipping point, where blood uric acid levels rise above a certain level known as the ‘saturation point’ which is approximately 6-7 mg/dL.1-3 This excess in uric acid in the blood is almost always the result of either and/or both of two different scenarios:
- Increased production of uric acid due to purine metabolism (breakdown of DNA and RNA molecules in the body)
- Decreased urinary excretion of uric acid by the kidneys
Genetic factors can also play a role in the above processes, but account for only approximately 6% of variation in blood uric acid levels amongst individuals.4 For individuals that do have a genetic component to gout, 90% of them suffer from the latter of the above two processes—poor urinary clearance of uric acid leading to hyperuricemia.5
DIET AND LIFESTYLE COMPONENTS OF GOUT
Diet and lifestyle factors play a big role in the development of gout. This is actually good news because these factors are modifiable by the person affected by gout. In essence, you have partial control over this aspect of whether or not you get gout or the degree of severity of gout should you come down with it. In particular, the choices made on a daily basis with what you eat play a large role in whether or not you are susceptible to gout. The study below highlights this point.
In the 2011 study titled, Risk Factors for Gout and Prevention: A Systemic Review of the Literature, investigators found that alcohol consumption (especially beer and liquor) along with meat/seafood consumption posed a significant increase in risk for developing gout.6 In addition, the consumption of sugar sweetened beverages and foods high in fructose also increased gout risk.
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