The Cytotoxicity Against Cancer without Harming to Nearby Healthy Cells of Herbal Fennel, Studies Showed

Kyle J. Norton

Fennel may have a potential and positive effect in induction of cytoprotection and antitumor activity against cancer expression, some scientists suggested.

The results of fennel efficacy were reported by several respectable institutes including National Cancer Institute and National Institute of Health.

Fennel (Foeniculum vulgare) is a plant species of genus, belongings to Apiaceae (Umbelliferae), native to the Mediterranean, used in traditional and herbal medicine as warming, carminative, antispasmodic, antidepressant agent and to stimulate the appetite, ease indigestion, soothe coughing, reduce intestinal spasms, to regulate the menstrual cycle and relieve PMS,…

Nutrients

1. Carbohydrates

2. Fiber

3. Protein

4. Thiamine (Vitamin B1)

5. Riboflavin (Vitamin B2)

6. Niacin (Vitamin B3)

7. Pantothenic acid (B5)

8. Vitamin B6

9. Folate (Vitamin B9)

10. Vitamin C

11. Calcium

12. Copper

13. Iron

14. Magnesium

15. Molybdenum

16. Phosphorus

17. Potassium

18. Zinc

In the study to evaluate the efficacy of fennel seed methanolic extract (FSME) for its antioxidant, cytotoxic, and antitumor activities and for its capacity to serve as a nontoxic radioprotector in Swiss albino mice through injection of FSME, 100 mg/kg intraperitoneally into mice bearing EAC before exposed to three 2-Gy doses of gamma irradiation, researchers found at after 30 days, the application extered a strong effect at the C50 (mean standard deviation 50% inhibitory concentrations) at dose of 50 μg/mL for the MCF7 breast cancer cell line and 48 μg/mL for the Hepg-2 liver cancer cell line.

* Reduced oxidative stress and protected mouse cells from damage caused by reactive oxygen species.

* Improved natural antioxidants and the oxidative stability of fatty foods during storage.

According to the results of experiment,

* In CWR22R tumors, application of all supplements exerted a similar effect in suppression the of the cancer cells.

* Intratumoral microvessel density was decreased in PC3 tumors treated with all five supplements but only in CWR22R tumors treated with HF.

According to the results of report, application of Ethanol extract of Foeniculum vulgare exhibited significant inhibition of cancer cells proliferation and induction of cancer cell apoptosis and reduction of growth of Klebsiella pneumonia, Serratia marcescens and Methicillin-resistant S. aureus. Pseudomonas aeruginosa

Taken together, fennel and its extracts may be used as function food in exertion of cytoprotection.

FOOD HACK for Weight Loss, A Simple Cooking Technique That Cuts The Calories & Glycemic Impact In Rice, Pasta, And Potatoes In Half 

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Author Biography

Kyle J. Norton (Scholar, Master of Nutrients, All right reserved)

Health article writer and researcher; Over 10.000 articles and research papers have been written and published on line, including world wide health, ezine articles, article base, healthblogs, selfgrowth, best before it’s news, the karate GB daily, etc.,.

Named TOP 50 MEDICAL ESSAYS FOR ARTISTS & AUTHORS TO READ by Disilgold.com Named 50 of the best health Tweeters Canada – Huffington Post

Nominated for shorty award over last 4 years

Some articles have been used as references in medical research, such as international journal Pharma and Bio science, ISSN 0975-6299.

Sources

(1) Antioxidant and anticarcinogenic effects of methanolic extract and volatile oil of fennel seeds (Foeniculum vulgare) by Mohamad RH1, El-Bastawesy AM, Abdel-Monem MG, Noor AM, Al-Mehdar HA, Sharawy SM, El-Merzabani MM.(PubMed)

(2) Antitumor activity of herbal supplements in human prostate cancer xenografts implanted in immunodeficient mice by Ng SS1, Figg WD.(PubMed)

(3) Study of anticancer and antibacterial activities of Foeniculum vulgare, Justicia adhatoda and Urtica dioica as natural curatives by Batool R1, Salahuddin H1, Mahmood T1, Ismail M2.(PubMed)