Sleep Deprivation Alters Liver Metabolism and Fat Content: Losing Just Six Hours of Sleep Could Increase Diabetes Risk
Sleep deprivation has been associated with eating more, moving less and having a higher risk of developing type 2 diabetes. However, a team of researchers from Toho University Graduate School of Medicine in Japan, explained, “It was not clear whether glucose intolerance was due to the changes in food intake or energy expenditure or to the sleep deprivation itself.”
Credit: BruceBlaus / Wikimedia Commons
The researchers measured glucose levels and fat content of the liver immediately after the trial period. Blood glucose levels were significantly higher in the sleep deprivation group than controls after one six-hour session of wakefulness. Triglyceride (fat) levels and the production of glucose in the liver also increased in the sleep deprivation group after a single wake period. Elevated liver triglycerides are associated with insulin resistance, or the inability of the body to process insulin properly. In addition, lack of sleep changed the expression of enzymes that regulate metabolism in the liver in the sleep deprivation group. These findings suggest that “intervention studies designed to prevent sleep deprivation-induced hepatic steatosis and insulin resistance should be performed in the future,” the researchers wrote.
Contacts and sources:
The American Physiological Society
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