Newly Discovered Compounds Shed Fresh Light On Whole Grain Health Benefits
“Whole grains are one of the healthiest foods there is. For instance, we know that a high intake of whole grains protects against type 2 diabetes and cardiovascular diseases. Up until now, however, we haven’t understood the cellular mechanisms through which a whole grain-rich diet impacts our body,” says Dr Kati Hanhineva, Principal Investigator of the study at the University of Eastern Finland.
“This is the first time many of these betaine compounds were observed in the human body in the first place,” Dr Hanhineva says.
At the end of the 12-week follow-up, the researchers also observed a correlation between improved glucose metabolism and increased presence of betaine compounds in the body.
“Pipecolic acid betaine, for example, is particularly interesting. Increased levels of pipecolic acid betaine after the consumption of whole grains was, among other things, associated with lower post-meal glucose levels.”
New compound worked similarly to a heart drug in cell level experiments
One of the betaine compounds discovered by the researchers is 5-aminovaleric acid betaine, 5-AVAB, which seems to cumulate in metabolically active tissues, such as the heart. With this observation in mind, the researchers set out to further test its effects in a cell model.
“We observed that 5-AVAB reduces cardiomyocytes’ use of fatty acids as a source of energy by inhibiting the function of a certain cell membrane protein,” Researcher Olli Kärkkäinen from the University of Eastern Finland says.
“This cell level effect is similar to that of certain drugs used for cardiovascular diseases. However, it is important to keep in mind that we haven’t proceeded beyond cell level experiments yet. We need further research in animals and humans to verify that 5-AVAB really can impact the function of our body.”
However, the discovery of the new compounds associated with whole grains significantly enhances our understanding of why whole grain products are good for our health.
“In the future, we seek to analyse in greater detail the multitude of effects these new compounds can have on the human body, and we will also look into how intestinal microbes possibly contribute to the formation of these compounds,” Dr Hanhineva continues.
The findings were reported in Scientific Reports and The American Journal of Clinical Nutrition. The study was funded by, e.g., the Academy of Finland, Business Finland and Biocenter Finland.
Dr Kati Hanhineva / Dr Olli Kärkkäinen
University of Eastern Finland
Citation: Diets rich in whole grains increase betainized compounds associated with glucose metabolism.
Olli Kärkkäinen, Maria A Lankinen, Marilena Vitale, Jenna Jokkala, Jukka Leppänen, Ville Koistinen, Marko Lehtonen, Rosalba Giacco, Natalia Rosa-Sibakov, Valérie Micard, Angela A A Rivellese, Ursula Schwab, Hannu Mykkänen, Matti Uusitupa, Marjukka Kolehmainen, Gabriele Riccardi, Kaisa Poutanen, Seppo Auriola, Kati Hanhineva. The American Journal of Clinical Nutrition, 2018; DOI: 10.1093/ajcn/nqy169
Whole grain intake associated molecule 5-aminovaleric acid betaine decreases β-oxidation of fatty acids in mouse cardiomyocytes. Kärkkäinen et al. Sci Rep. 2018, http://doi.org/10.1038/s41598-018-31484-5
Source:
Anyone can join.
Anyone can contribute.
Anyone can become informed about their world.
"United We Stand" Click Here To Create Your Personal Citizen Journalist Account Today, Be Sure To Invite Your Friends.
Please Help Support BeforeitsNews by trying our Natural Health Products below!
Order by Phone at 888-809-8385 or online at https://mitocopper.com M - F 9am to 5pm EST
Order by Phone at 866-388-7003 or online at https://www.herbanomic.com M - F 9am to 5pm EST
Order by Phone at 866-388-7003 or online at https://www.herbanomics.com M - F 9am to 5pm EST
Humic & Fulvic Trace Minerals Complex - Nature's most important supplement! Vivid Dreams again!
HNEX HydroNano EXtracellular Water - Improve immune system health and reduce inflammation.
Ultimate Clinical Potency Curcumin - Natural pain relief, reduce inflammation and so much more.
MitoCopper - Bioavailable Copper destroys pathogens and gives you more energy. (See Blood Video)
Oxy Powder - Natural Colon Cleanser! Cleans out toxic buildup with oxygen!
Nascent Iodine - Promotes detoxification, mental focus and thyroid health.
Smart Meter Cover - Reduces Smart Meter radiation by 96%! (See Video).
Alton Parrish, I do appreciate your postings on health. Some really good articles. But, this one on grain is confusing to me. It seems there are two views on grains. There are many researchers and authors who say that any type of grain is not good for you. And, they back it up with all of these studies. So, then there is your group which says that at least the whole grains are good for you and it too is backed up with scientific studies. What are we to believe?