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Nasal Spray That Protects Against COVID-19 Is Also Effective Against the Common Cold

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Research into a new drug which primes the immune system in the respiratory tract and is in development for COVID-19 shows it is also effective against rhinovirus. Rhinovirus is the most common respiratory virus, the main cause of the common cold and is responsible for exacerbations of chronic respiratory diseases such as asthma and chronic obstructive pulmonary disease. In a study recently published in the European Respiratory Journal (LINK), the drug, known as INNA-X, is shown to be effective in a pre-clinical infection model and in human airway cells.

Fig 1. Researchers were able to use cells from human donors and re-grow the structure of the airway surface, the epithelium, to recreate the first line of defense against respiratory viruses.This model of the human airway was key to researchers showing that INNA-X can directly activate your airway epithelium so that it is better prepared to repel viruses and protect you from disease.

Credit: HMRI

Treatment with INNA-X prior to infection with rhinovirus significantly reduced viral load and inhibited harmful inflammation.

University of Newcastle and Hunter Medical Research Institute (HMRI) researcher Associate Professor Nathan Bartlett, who led the study, said INNA-X showed great promise as a new way to protect people from diseases caused by common respiratory viruses such as rhinovirus. These diseases range from the common cold to potentially life-threatening exacerbations of chronic respiratory diseases, which cost the global economy billions of dollars each year.

Fig 2. Associate Professor Nathan Bartlett holds a mockup of the immune boosting nasal spray in the HMRI labs in Newcastle, Australia.

 Credit: HMRI

“Consistent with what we have reported for other respiratory viruses including SARS-CoV-2 (the virus that causes COVID-19), INNA-X treatment prior to infection reduced the level of virus in the respiratory tract,” Associate Professor Bartlett said.

“We have also examined the effect of INNA-X in airway cells from patients with asthma which we know have a less effective anti-viral immune response and found that INNA-X treatment was effective providing a rationale for the use of INNA-X in at risk populations.”

INNA-X is developed by the Australian biotech company Ena Respiratory and works by stimulating the innate immune system in the airways, the first line of defense against the invasion of respiratory viruses into the body. This immune priming makes it much more difficult for viruses such as rhinoviruses to take hold, cause serious symptoms and spread.

INNA-X has been also shown to be highly effective at reducing virus shedding of SARS-CoV-2 and human trials of Ena Respiratory’s clinical candidate INNA-051 will begin in Australia in the coming weeks.

“If found protective, this could be used by at risk populations including elderly or asthma patients, to reduce the severity of rhinovirus, COVID-19 and other respiratory viruses’ infections in conjunction with vaccine approaches,” Associate Professor Bartlett said.

Fig 3. A closeup of a mockup of the immune boosting nasal spray in the HMRI labs in Newcastle, Australia

Credit: HMRI

INNA-X has been also shown to be highly effective at reducing virus shedding of SARS-CoV-2 and human trials of Ena Respiratory’s clinical candidate INNA-051 will begin in Australia in the coming weeks.

“If found protective, this could be used by at risk populations including elderly or asthma patients, to reduce the severity of rhinovirus, COVID-19 and other respiratory viruses’ infections in conjunction with vaccine approaches,” Associate Professor Bartlett said.

* HMRI is a partnership between the University of Newcastle, Hunter New England Health, and the community.

About Ena Respiratory

Ena Respiratory is aiming to transform the treatment and prevention of respiratory infections, including COVID-19 in at-risk populations.

Ena Respiratory is developing novel, synthetic innate immunomodulators for the prevention of respiratory viral and bacterial infections. The company is based in Melbourne and Sydney, Australia.

 
 

Contacts and sources:
Sam Cardwell
Hunter Medical Research Institute

 

 


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    • califoregonian

      DO NOT TAKE THIS!!!

      It’s laced with carageenan, which is a highly dangerous FDA-loved “food safe” additive. It’s not safe at all! It’s extremely inflammatory, causing intestinal lesions when taken internally.

      I was having severe nausea, vomiting, upset, stabbing pains, and it didn’t seem to matter if I ate “nice” foods or “junk” foods. Until I started looking into the additives. Once I started avoiding carageenan, guar gum, or other thickeners used in things like non-dairy “milk” or even in most “ice cream” brands.

      I experimented, cutting out anything with carageenan. Stomach improved. Ate a pint of vanilla ice cream with carageenan, and wham, puking, diarrhea, the works.

      Ate the same thing, only natural ice cream, and no problems at all. Happy tummy!

      Every time I didn’t check the label and had gut pain or throwing up after eating something, carageenan was on the label. Too much xanthan gum, guar gum, etc., also caused symptoms, but carageenan was the worst of all.

      Pigs were fed carageenan and after just 72 hours on this diet they had lesions –holes– burned in their intestines by it.

      This nasal spray is intended to make you more unhealthy, which is why they want you snorting it (and hence dripping into your guts from the sinus) daily.

      AVOID THIS and ALL CARAGEENAN-CONTAINING PRODUCTS!!!!!

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