The Corona pandemic in detail

The spread of the coronavirus is at a very fast rate 

1. Coming and going

2. Since March 2019

3. Natural spread

4. Cross-reactivity

5. Therapy

1. Coming and going

The agents of the disease Covid-19 (Sars-CoV-2, and the so-called Iranian, Italian, British, South African, Brazilian, Indian mutants, variants, strains, clades) are non-novel viruses that lived peacefully with/in an animal, mutated in it so that they could infect humans, and then mutated in them again into lethal guests that could cause a pandemic with the death of, say, 20% of the earth’s inhabitants.

The 2003 Sars-Cov-1 coronavirus, with much higher mortality than the current Sars-CoV-2, disappeared in 2003 without lockdown or vaccination. Likewise, the Mers-CoV coronavirus in2012. The initial, proven Sars-CoV-2 has apparently died out in the UK and many other countries as well without vaccination and with inadequate lockdowns. China’s 1.4 billion people have been free of Sars-CoV-2 since19.03.20.[1]

Tanzania is free of “Corona” since May 2020, without lockdown and vaccination, Equatorial Guinea since 13.08.2020. Australia and New Zealand are almost free of deaths since August 2020 after previous light lockdowns and without vaccination. Vietnam, North Korea, Taiwan, Hong Kong, Zimbabwe, Uruguay have few Sars-CoV-2 deaths without vaccination.

[1] Coronavirus in China: Keine neuen Infektionen gemeldet. Update vom 19. März, 6.15 Uhr: Zum ersten Mal seit dem Ausbruch des neuartigen Coronavirus Anfang Januar hat China landesweit keine lokalen Neuinfektionen mehr gemeldet. In China hat jetzt trotz Corona das landesweit größte Bierfest angefangen. Hunderttausende Besucher werden erwartet. 04.08.2020, 16:54. www.merkur.de

Mitte Mai 2020 wurde der letzte Coronatote in China dokumentiert (afp/aerzteblatt.de Zahl der Coronafälle in Wuhan offenbar höer als gemeldet. Deutsches Ärzteblatt 30.12.2020).

TagesschauTV. 12.9.2021 „China hatte die Ausbreitung des Cornavirus nach einer ersten Welle Anfang 2020 weitgehend eingedämmt. Durch die Delta-treten aber inzwischen immer wieder kleinere Virus-Cluster auf. Meist machen die Behörden dafür Menschen verantwortlich, die aus dem Ausland eingereist sind.“

“In China gibt es seit Monaten kaum lokale Fälle und damit auch praktisch kein Risiko, sich anzustecken.“ (Kretschmer F. China das Land der Impfskeptiker ist jetzt Impfweltmeister. RND 02.06.2021).

Erste Testimpfungen wurden an Militärangehörigen im Juni 2020 vorgenommen. Impfungen mit dem chinesischen Produkt sinopharm wurden ab dem 31.12.20 an den Corona-freien Menschen in China vorgenommen.

Of the 30 countries with the lowest rate of Corona deaths, 20 are in Africa[1], nine in Asia, and New Zealand (11th place) in Australia. Of the 30 countries with the highest rate of corona deaths, 21 are in Europe, eight in America, and Armenia in Asia. In Europe, in ascending order of rates of corona deaths, the countries affected are Iceland, Norway, Monaco, Finland, Belarus, Estonia, Denmark, Latvia, Ukraine, and Ireland.

In countries in Africa, the Sars-CoV-2 types kill relatively few people.

In Taiwan, Vietnam, China, Singapore also relatively few.

The USA has the third-highest rate of corona deaths, Brazil the 24th highest, Russia the 46th highest, India the 76th highest.[2]

2. Mass infections of Sars-CoV-2 since March 2019.

It is likely that outbreaks of severe coronaviruses have occurred before.

Evidence and evidence of the widespread Sars-CoV-2 since March 2019 has been published for Hubei Province in China as well as for the USA, Spain, Italy, France after a pandemic was declared.

– Sars-CoV-2 was subsequently detectable in sewage from Barcelona as early as 12 March 2019.[3]

That SARS-CoV-2 can be detected in sewage before it becomes medically apparent has been shown in the Netherlands. In Amersfoort, SARS-CoV-2 was detected in wastewater on 05.03.2021. On 11.03.2021, SARS-CoV-2 was detected in people there for the first time.[4]

• Since August 2019 or early autumn 2019, activities and disease symptoms characteristic of COVID-19 can be detected around Wuhan, China.[5]
   
• On 30 January 2020, the first cases of Covid-19 were reported in Rome, Italy, namely two tourists from China, and on 21 February 2020, the first case of indigenous infection was reported in Codognol, Italy.
   
• However, SARS-CoV-2 antibodies have already been subsequently detected in 111 (11.6%) of 959 serum samples from healthy subjects from 03/09/2019 to 10/02/2020.

[1] s. z.B. Ojal J, Brand SPC, Were V et al. Revealing the extent of the COVID-19 pandemic in Kenya based on serological and PCR-test data. medRxiv BMJ Yale 03.09.2020

[2] https://coronavirus.jhu.edu/data/mortality

[3] Chavarria-Miró G, Anfruns-Estrada E, Guix S, et al. Sentinel surveillance of SARS-CoV-2 in wastewater anticipates the occurrence of COVID-19 cases. medRxiv BMJ, June 13, 2020

[4] Medema G, Heijnen L, Elsinga G, et al. Presence of SARS-Coronavirus-2 RNA in Sewage and Correlation with Reported COVID-19 Prevalence in the Early Stage of the Epidemic in The Netherlands. Environ. Sci. Technol. Lett. 2020, 7, 7, 511-516

[5] Nsoesie EO, Rader B, Barnoon YL, et al. Analysis of hospital traffic and search engine data in Wuhan China indicates early disease activity in the Fall of 2019.

• The number of mostly asymptomatic infected persons in Italy must therefore be assumed to be five times greater than indicated by the Italian government.[1]
   
• A global spread of SARS-CoV-2 since October 2019 was calculated retrospectively.[2]
   
• Researchers in the US have indicated “the period between mid-October and mid-November 2019″ as the likely time during which the first case of SARS-CoV-2 emerged in Hubei Province.” [3]
   
• The actual US numbers calculated for 4 April 2020 were 8.1 million Corona-infected people, 26 times greater than the 311,000 officially identified.[4] The statistical curves allow us to calculate the start of the infections before 2020. Assuming exponential growth with infected persons doubling every seven days, the first infection would have to have occurred on 21 October 2019.

For France, the first two infections with SARS-CoV-2 were reported on 24 January 2020. Both individuals had been in Wuhan, China.

• But for the period between November 2019 and January 2020, 13 infections due to SARS-CoV-2 have been detected in France.[5]
   
• Verified by subsequent radiological diagnosis, cases of Covid-19 occurred in the Colmar region, France on 16 November 2019.[6]
   
• Antibodies to Sars-CoV-2 have been found retrospectively in US Red Cross blood supplies from nine states in the US since 13 Dec 2019.[7]
• In early December 2019, the virus was subsequently detectable in the throat swab of a boy in Milano, Italy who had fallen ill on 30 Nov 2019.[8]
   
• Sars-CoV-2 was subsequently detectable in sewage from Milano and Turin on 18 December 2019 and from Bologna on 29 January 2020.[9]

[1] Apolone G, Montomoli E, Manenti A, et al. Unexpected detection of SARS-CoV-2 antibodies in the pre-pandemic period in Italy. Tumori Journal, Nov 11, 2020

[2] VanDorp L, Acman M, Richard D, et al. Emergence of genomic diversity and recurrent mutations in SARS-CoV-2. Infection, Genetics, and Evolution. May 05, 2020

[3] Pekar J, Worobey, M, Moshiri N, et al. Timing the SARS-CoV-2 Index Case in Hubei Province. bioRxiv. Version 1. Preprint. 2020 Nov 24

[4] Lu FS, Nguyen AT, Link NB, et al. Estimating the Cumulative Incidence of COVID-19 in the United States Using Four Complementary Approaches. Mauricio Santillana ([email protected]) Preprint

[5] Carrat F, Figoni J, Henny J, et al. Evidence of early circulation of SARS-CoV-2 in France: findings from the population-based “CONSTANCE” cohort. Eur J Epidemiol 36, 2019-222 (2021). https://doi.org/10.1007/s10654-020-00716-2

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